Author profile: Smani Hajami, Tarik
Institutional data
| Name | Smani Hajami, Tarik |
| Department | Fisiología Médica y Biofísica |
| Knowledge area | Fisiología |
| Professional category | Catedrático de Universidad |
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Statistics
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No. publications
43
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No. visits
5146
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No. downloads
7497
| Publications |
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PhD Thesis
 Remodelado de la entrada de calcio operada por los reservorios y su regulación por micrornas en la reestenosis vascular
(2024)
La cardiopatía isquémica constituye la principal causa de muerte en relación con las enfermedades cardiovasculares. Su ... |
Article
 Valor pronóstico de la bioimpedancia eléctrica medida con el dispositivo IVOL en la insuficiencia cardiaca aguda
(Elsevier, 2024)
Introducción y objetivos: La evaluación actual de la insuficiencia cardiaca (IC) aguda no permite predecir adecuadamente ... |
PhD Thesis
Caracterización del papel de las poblaciones inflamatorias en el infarto revascularizado y sus implicaciones en el remodelado adverso
(2023)
La revascularización temprana después del infarto permite reestablecer el flujo sanguíneo a la zona infartada del corazón ... |
Article
Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation
(MDPI, 2022)
N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction with ... |
PhD Thesis
Evaluación de la imagen multimodal para la impresión 3D en cardiopatías congénitas: docencia, aplicaciones clínicas y perspectivas futuras
(2022)
Las cardiopatías congénitas son las malformaciones presentes al nacimiento más frecuentes, y tienen un impacto muy ... |
PhD Thesis
Remodelado de la entrada de calcio en la angiogénesis: papel de las proteínas ORAI1 Y SARAF
(2022)
La angiogénesis se define como el proceso llevado a cabo por las células endoteliales (CE) por el cual se forman nuevos ... |
Article
Tissue engineered in-vitro vascular patch fabrication using hybrid 3D printing and electrospinning
(Elsevier, 2022)
Three-dimensional (3D) engineered cardiovascular tissues have shown great promise to replace damaged structures. Specifically, ... |
Article
Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells
(Springer, 2022)
The identification of two variants of the canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel ... |
Article
Predicted Value of MicroRNAs, Vascular Endothelial Growth Factor, and Intermediate Monocytes in the Left Adverse Ventricular Remodeling in Revascularized ST-Segment Elevation Myocardial Infarction Patients
(Frontiers Media S.A, 2022)
Background: Primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction ... |
Article
 Cardiac protection induced by urocortin-2 enables the regulation of apoptosis and fibrosis after ischemia and reperfusion involving miR-29a modulation
(CELL PRESS (Elsevier), 2022)
Urocortin-2 (Ucn-2) has demonstrated cardioprotective ac tions against myocardial ischemia-reperfusion (I/R) injuries. Herein, ... |
Article
Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells
(MDPI, 2021)
Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity ... |
Article
Editorial: A Compendium of Recent Research on Stem Cell-Based Therapy for Covid-19
(Frontiers Media, 2021)
We have been dealing with an unprecedented global health crisis for nearly 2 years now. This started after an outbreak of ... |
Article
Urocortin Role in Ischemia Cardioprotection and the Adverse Cardiac Remodeling
(MDPI, 2021)
Despite the considerable progress in strategies of myocardial protection, ischemic heart diseases (IHD) and consequent ... |
Article
Editorial: Molecular Components of Store-Operated Calcium Entry in Health and Disease
(Frontiers Media, 2021)
Store-Operated Calcium Entry (SOCE) is a ubiquitous Ca2+ influx mechanism first described in 1986 (Putney, 1986). This ... |
PhD Thesis
Remodelado ventricular adverso tras reperfusión aguda. Efecto cardioprotector de la Urocortina-2
(2021)
Las enfermedades cardiovasculares son la principal causa de muerte en el mundo desarrollado, siendo tres de ellas las más ... |
Article
Furin prodomain ppfurin enhances ca2+ entry through orai and trpc6 channels’ activation in breast cancer cells
(MDPI, 2021)
Furin, a proprotein convertase that belongs to a family of Ca2+-dependent serine peptidases, is involved in the maturation ... |
Article
miR-30b-5p Downregulation as a predictive biomarker of coronary in-stent restenosis
(2021)
In-stent restenosis (ISR) is one of the main limitations of percutaneous coronary intervention (PCI) therapy with drug-eluting ... |
Article
Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases
(Fontiers Media SA, 2021)
The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and ... |
Article
SARAF and Orai1 contribute to endothelial cell activation and angiogenesis
(FRONTIERS MEDIA SA, 2021)
Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form new blood vessels from ... |
Article
SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells
(MDPI, 2021)
Breast cancer is among the most common malignancies in women. From the molecular point of view, breast cancer can be grouped ... |
Article
Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple negative breast cancer cells
(Amer Soc Biochemistry Molecular Biology Inc, 2021)
Melatonin has been reported to induce effective reduction in growth and development in a variety of tumors, including ... |
Article
TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease
(doi:10.3390/ijms21176125, 2020)
Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They ... |
Article
Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors.
(2020)
Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several ... |
Article
Innate Immune Receptors, Key Actors in Cardiovascular Diseases
(Elsevier on behalf of the American College of Cardiology Foundation, 2020)
Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with ... |
Article
TRPC Channels in the SOCE Scenario
(MDPI, 2020)
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation ... |
Article
TRPC Channels: Dysregulation and Ca2+ Mishandling in Ischemic Heart Disease
(doi:10.3390/cells9010173, 2020)
Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac ... |
Article
Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells
(2019)
Orai1 plays a major role in store-operated Ca 2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel ... |
Article
TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling
(Frontiers Media, 2019)
Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also ... |
Article
EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction
(S. Karger AG, 2018)
Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved ... |
Article
TRPC6 channels are required for proliferation, migration and invasion of breast cancer cell lines by modulation of Orai1 and Orai3 surface exposure
(MDPI AC, 2018)
Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular ... |
Article
miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation
(The American Society of Gene and Cell Therapy, 2018)
Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this ... |
Article
Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion
(Frontiers Research Foundation, 2018)
Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is ... |
Article
The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells
(Frontiers Media, 2018)
Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. ... |
| PhD Thesis |
Article
miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemiareperfusion injury
(Nature Research, 2017)
Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemiareperfusion (I/R) ... |
PhD Thesis
Estudio molecular de la cardioprotección inducida por Urocortina frente al síndrome de isquemia/repercusión.
(2016)
Las enfermedades cardiovasculares siguen siendo la principal causa de morbimortalidad en los países desarrollados (Figura ... |
Article
STIM and Orai1 Variants in Store-Operated Calcium Entry
(Frontiers Research Foundation, 2016)
Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx ... |
Article
Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells
(American Society for Biochemistry and Molecular Biology, 2016)
Voltage-dependent CaV1.2 L-type Ca2 channels (LTCC) are the main route for calcium entry in vascular smooth muscle ... |
Article
Urocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery Role of EPAC2 and ERK12
(Public Library of Science, 2016)
Urocortin-1 (Ucn-1) is an endogenous peptide that protects heart from ischemia and reperfusion (I/R) injuries. Ucn-1 is ... |
Article
Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells
(Public Library of Science, 2015)
Human embryonic stem cells (hESCs) retain the extraordinary capacity to differentiate into different cell types of an adult ... |
PhD Thesis
Implicación de la entrada de calcio regulada por los reservorios en la vasoconstricción y proliferación inducida por urotensina-ii en aorta
(2012)
En los últimos años, la terminación de la primera parte del Proyecto Genoma Humano ha traído consigo la identificación de ... |
PhD Thesis
Potenciación de los Mecanismos Endógenos de Protección Miocárdica frente al síndrome de Isquemia-Reperfusión
(2009)
Antecedentes: La cardiopatía isquémica es la principal causa de morbilidad y mortalidad en las sociedades desarrolladas, ... |
PhD Thesis
Homeostasis del calcio en miocitos del árbol arterial pulmonar
(2000)
En el presente trabajo se ha estudiado la homeostasis de la (Ca2+) i en miocitos aislados de la arteria pulmonar y el ... |