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SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons

 

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Opened Access SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
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Author: Romeo Guitart, David
Leiva Rodríguez, Tatiana
Espinosa Alcantud, María
Sima, Núria
Vaquero, Alejandro
Domínguez Martín, Helena
Ruano Caballero, Diego
Casas, Catalina
Department: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular
Date: 2018
Published in: Cell Death and Disease, 9 (5), 531-.
Document type: Article
Abstract: Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury. SIRT2 has been suggest...
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Cite: Romeo Guitart, D., Leiva Rodríguez, T., Espinosa Alcantud, M., Sima, N., Vaquero, A., Domínguez Martín, H.,...,Casas, C. (2018). SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons. Cell Death and Disease, 9 (5), 531-.
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URI: https://hdl.handle.net/11441/87294

DOI: 10.1038/s41419-018-0553-6

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