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Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells

 

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Opened Access Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells
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Author: Jiménez Guerrero, Rocío
Gasca Bellido, Jessica María
Flores, M. Luz
Pérez Valderrama, Begoña
Medina, Rafael
Tortolero García, María Dolores
Romero Portillo, Francisco
Japón Rodríguez, Miguel Ángel
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2018
Published in: Cancer, 10 (12, 490), 1-17.
Document type: Article
Abstract: Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits. Mcl-1 is an anti-apoptotic protein that promotes resistance to pa...
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Cite: Jiménez Guerrero, R., Gasca Bellido, J.M., Flores, M.L., Pérez Valderrama, B., Medina, R., Tortolero García, M.D.,...,Japón Rodríguez, M.Á. (2018). Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells. Cancer, 10 (12, 490), 1-17.
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URI: https://hdl.handle.net/11441/81597

DOI: 10.3390/cancers10120490

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