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dc.creatorSarmiento Soto, Manueles
dc.creatorSibson, Nicola R.es
dc.date.accessioned2018-11-30T11:55:28Z
dc.date.available2018-11-30T11:55:28Z
dc.date.issued2018
dc.identifier.citationSarmiento Soto, M. y Sibson, N.R. (2018). The Multifarious Role of Microglia in Brain Metastasis. Frontiers in Cellular Neuroscience, 12 (414), 1-7.
dc.identifier.issn1662-5102es
dc.identifier.urihttps://hdl.handle.net/11441/80683
dc.description.abstractThe immune landscape in brain metastasis is a very heterogeneous framework. Amongst a broad plethora of cells within the tumor microenvironment, the presence of activated microglia has been perfectly described. The innate role of microglial cells is to detect and eliminate any insults that may disturb the regular behavior of the brain. As part of its defensive role, it releases pro- and anti-inflammatory cytokines that aim to modulate the inflammatory scenario at the metastatic foci. However, the long term effects that these cells may exert on the metastatic progression is not clear. One of the biggest challenges in the field is to distinguish between brain resident microglial cells and infiltrated bone-marrow derived macrophages. Part of this issue is the fact that both cell types share similar phenotypes. Current studies are based on the modulation of the immune response against cancer cells (immunotherapy). However, most of current clinical trials and newly developed drugs focus on the adaptive immune response (e.g., immune blockade check-points). Additionally, the unique structure of the central nervous system with the presence of the blood-brain barrier have hindered a significant advance in novel therapies against brain metastasis. In this manuscript, we describe current advances in characterization of tumor-associated microglia and macrophages, the importance of microglia during the anti-cancerous response, and the future direction for the development of new strategies against this complex disease.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.ispartofFrontiers in Cellular Neuroscience, 12 (414), 1-7.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmicrogliaes
dc.subjectmacrophageses
dc.subjectbraines
dc.subjectmetastasises
dc.subjectcanceres
dc.subjecttherapieses
dc.titleThe Multifarious Role of Microglia in Brain Metastasises
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica y Biología Moleculares
dc.relation.publisherversionhttp://dx.doi.org/10.3389/fncel.2018.00414es
dc.identifier.doi10.3389/fncel.2018.00414es
idus.format.extent7 p.es
dc.journaltitleFrontiers in Cellular Neurosciencees
dc.publication.volumen12es
dc.publication.issue414es
dc.publication.initialPage1es
dc.publication.endPage7es

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