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Microcontroller-Based Sinusoidal Voltage Generation for Electrical Bio-Impedance Spectroscopy Applications

 

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Opened Access Microcontroller-Based Sinusoidal Voltage Generation for Electrical Bio-Impedance Spectroscopy Applications
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Author: Castro García, Juan Antonio
Olmo Fernández, Alberto
Pérez García, Pablo
Yúfera García, Alberto
Department: Universidad de Sevilla. Departamento de Tecnología Electrónica
Date: 2016
Published in: Journal of Computer and Communications, 4 (17), 51-58.
Document type: Article
Abstract: A sinusoidal voltage wave generator is proposed based on the use of micro- processor digital signals with programmable duty-cycles, with application to real-time Electrical Cell-substrate Impedance Spectroscopy (ECIS) assays in cell cultures. The working principle relies on the time convolution of the programmed microcontroller (μC) digital signals. The expected frequency is easily tuned on the bio-impedance spectroscopy range [100 Hz, 1 MHz] thanks to the μC clock frequency selection. This system has been simulated and tested on the 8 bits μC Arduino™ Uno with ATmega328 version. Results obtained prove that only three digital signals are required to fit the general specification in ECIS experiments, below 1% THD accuracy, and show the appropriateness of the system for the real-time monitoring of this type of biological experiments.
Cite: Castro García, J.A., Olmo Fernández, A., Pérez García, P. y Yúfera García, A. (2016). Microcontroller-Based Sinusoidal Voltage Generation for Electrical Bio-Impedance Spectroscopy Applications. Journal of Computer and Communications, 4 (17), 51-58.
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URI: https://hdl.handle.net/11441/80237

DOI: 10.4236/jcc.2016.417003

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