dc.creator | Sánchez Romero, María Antonia | es |
dc.creator | Casadesús Pursals, Josep | es |
dc.date.accessioned | 2018-10-16T09:20:29Z | |
dc.date.available | 2018-10-16T09:20:29Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sánchez Romero, M.A. y Casadesús Pursals, J. (2018). Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis. Scientific Reports, 8, 1-11. | |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://hdl.handle.net/11441/79434 | |
dc.description.abstract | Salmonella enterica pathogenicity island 1 (SPI-1) is a gene cluster that encodes a type III secretion system and effectors involved in epithelial cell invasion. SPI-1 undergoes bistable expression, with concomitant formation of SPI-1ON and SPI-1OFF lineages. This study describes single cell analysis of SP1-1 bistability and epithelial cell invasion, and reports the unsuspected observation that optimal invasion of epithelial cells requires the presence of both SPI-1ON and SPI-1OFF subpopulations. The contribution of SPI-1OFF cells to optimal invasion may rely on their ability to invade epithelial cells if a SPI-1ON subpopulation is present. In fact, Salmonella SPI-1 mutants are also able to invade epithelial cells in the presence of SPI-1ON Salmonellae, a phenomenon described in the 1990’s by Galán and co-workers. Invasion by SPI-1OFF cells does not seem to involve a diffusible factor. A small number of SPI-1ON cells is sufficient to endow the bacterial population with invasion capacity, a feature that may permit host colonization regardless of the bottlenecks encountered by Salmonella populations inside animals. | es |
dc.description.sponsorship | España, MINECO BIO2016-75235-P | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Natural Research | es |
dc.relation.ispartof | Scientific Reports, 8, 1-11. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | BIO2016-75235-P | es |
dc.relation.publisherversion | http://dx.doi.org/10.1038/s41598-018-33137-z | es |
dc.identifier.doi | 10.1038/s41598-018-33137-z | es |
idus.format.extent | 11 p. | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 8 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 11 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |