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Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis

 

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dc.creator Sánchez Romero, María Antonia es
dc.creator Casadesús Pursals, Josep es
dc.date.accessioned 2018-10-16T09:20:29Z
dc.date.available 2018-10-16T09:20:29Z
dc.date.issued 2018
dc.identifier.citation Sánchez Romero, M.A. y Casadesús Pursals, J. (2018). Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis. Scientific Reports, 8, 1-11.
dc.identifier.issn 2045-2322 es
dc.identifier.uri https://hdl.handle.net/11441/79434
dc.description.abstract Salmonella enterica pathogenicity island 1 (SPI-1) is a gene cluster that encodes a type III secretion system and effectors involved in epithelial cell invasion. SPI-1 undergoes bistable expression, with concomitant formation of SPI-1ON and SPI-1OFF lineages. This study describes single cell analysis of SP1-1 bistability and epithelial cell invasion, and reports the unsuspected observation that optimal invasion of epithelial cells requires the presence of both SPI-1ON and SPI-1OFF subpopulations. The contribution of SPI-1OFF cells to optimal invasion may rely on their ability to invade epithelial cells if a SPI-1ON subpopulation is present. In fact, Salmonella SPI-1 mutants are also able to invade epithelial cells in the presence of SPI-1ON Salmonellae, a phenomenon described in the 1990’s by Galán and co-workers. Invasion by SPI-1OFF cells does not seem to involve a diffusible factor. A small number of SPI-1ON cells is sufficient to endow the bacterial population with invasion capacity, a feature that may permit host colonization regardless of the bottlenecks encountered by Salmonella populations inside animals. es
dc.description.sponsorship España, MINECO BIO2016-75235-P es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Natural Research es
dc.relation.ispartof Scientific Reports, 8, 1-11.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Contribution of SPI-1 bistability to Salmonella enterica cooperative virulence: insights from single cell analysis es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Genética es
dc.relation.projectID BIO2016-75235-P es
dc.relation.publisherversion http://dx.doi.org/10.1038/s41598-018-33137-z es
dc.identifier.doi 10.1038/s41598-018-33137-z es
idus.format.extent 11 p. es
dc.journaltitle Scientific Reports es
dc.publication.volumen 8 es
dc.publication.initialPage 1 es
dc.publication.endPage 11 es
dc.contributor.funder Ministerio de Economía y Competitividad (MINECO). España
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