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Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain

Opened Access Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain

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Autor: Rodríguez Matarredona, Esperanza
Talaverón Aguilocho, Rocío
Pastor Loro, Ángel Manuel
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2018
Publicado en: Frontiers in Cellular Neuroscience, 12 (268), 1-11.
Tipo de documento: Artículo
Resumen: The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells (NPCs) that continuously produce neuroblasts throughout life. These neuroblasts migrate towards the olfactory bulb where they differentiate into local interneurons. The neurogenic niche of the SVZ includes, in addition to NPCs and neuroblasts, astrocytes, ependymal cells, blood vessels and the molecules released by these cell types. In the last few years, microglial cells have also been included as a key component of the SVZ neurogenic niche. Microglia in the SVZ display unique phenotypic features, and are more densely populated and activated than in non-neurogenic regions. In this article we will review literature reporting microglia-NPC interactions in the SVZ and the role of this bilateral communication in microglial function and in NPC biology. This interaction can take place through the release of soluble factors, extracellular vesicles or gap junctional communication. In addition, as NPCs...
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Cita: Rodríguez Matarredona, E., Talaverón Aguilocho, R. y Pastor Loro, Á.M. (2018). Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain. Frontiers in Cellular Neuroscience, 12 (268), 1-11.
Tamaño: 1.499Mb
Formato: PDF

URI: https://hdl.handle.net/11441/78519

DOI: 10.3389/fncel.2018.00268

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