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Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations


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Opened Access Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations

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Author: Pérez García, Pablo
Huertas Sánchez, Gloria
Olmo Fernández, Alberto
Maldonado-Jacobi, Andrés
Serrano Viseas, Juan Alfonso
Martín Rubio, María Esther
Daza Navarro, María Paula
Yúfera García, Alberto
Coordinator/Director: Rueda Rueda, Adoración
Sánchez Aguayo, Inmaculada
Department: Universidad de Sevilla. Departamento de Tecnología Electrónica
Universidad de Sevilla. Departamento de Electrónica y Electromagnetismo
Universidad de Sevilla. Departamento de Biología Celular
Date: 2018
Published in: Sensor, 18 (8), 1-13.
Document type: Article
Abstract: A smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable “biological” oscillator. The system enables the remote acquisition and management of the “biological” oscillation signals through a secure web interface. The indirectly observed biological properties are cell growth and cell number, which are straightforwardly related to the measured bio-oscillation signal parameters, i.e., frequency and amplitude. The sensor extracts the information without complex circuitry for acquisition and measurement, taking advantage of the microcontroller features. A discrete prototype for sensing and remote monitoring is presented along with the experimental results obtained from the performed measurements, achieving the expected performance and outcomes.
Cite: Pérez García, P., Huertas Sánchez, G., Olmo Fernández, A., Maldonado-Jacobi, A., Serrano Viseas, J.A., Martín Rubio, M.E.,...,Yúfera García, A. (2018). Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations. Sensor, 18 (8), 1-13.
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Format: PDF


DOI: 10.3390/s18082550

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