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Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy

 

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Opened Access Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
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Author: Suárez Calvet, Xavier
Fernández Simón, Esther
Piñol Jurado, Patricia
Gallardo, Eduard
Gómez Gálvez, Pedro
Escudero Cuadrado, Luis María
Department: Universidad de Sevilla. Departamento de Biología Celular
Date: 2018
Published in: Cell Death and Disease, 9 (7), 776-1-776-15.
Document type: Article
Abstract: Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin deficiency induces instability of the sarcolemma during muscle contraction that leads to muscle necrosis and replacement of muscl...
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Cite: Suárez Calvet, X., Fernández Simón, E., Piñol Jurado, P., Gallardo, E., Gómez Gálvez, P. y Escudero Cuadrado, L.M. (2018). Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy. Cell Death and Disease, 9 (7), 776-1-776-15.
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URI: https://hdl.handle.net/11441/77990

DOI: 10.1038/s41419-018-0792-6

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