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A Tracking Algorithm For Cell Motility Assays in CMOS Systems

 

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Opened Access A Tracking Algorithm For Cell Motility Assays in CMOS Systems
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Author: Martínez Gómez, Cristina
Olmo Fernández, Alberto
Huertas Sánchez, Gloria
Pérez García, Pablo
Maldonado-Jacobi, Andrés
Yúfera García, Alberto
Department: Universidad de Sevilla. Departamento de Tecnología Electrónica
Universidad de Sevilla. Departamento de Electrónica y Electromagnetismo
Date: 2017
Published in: EMBC 2017: 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (2017), p 837-840
ISBN/ISSN: 978-1-5090-2809-2
1557-170X
Document type: Presentation
Abstract: This work proposes a method for the study and real-time monitoring of a single cell on a 2D electrode matrix, of great interest in cell motility assays and in the characterization of cancer cell metastasis. A CMOS system proposal for cell location based on occupation maps data generated from Electrical Cell-substrate Impedance Spectroscopy (ECIS) has been developed. From experimental assays data, an algorithm based on the analysis of the eight nearest neighbours has been implemented to find the cell center of mass. The path followed by a cell, proposing a Brownian route, has been simulated with the proposed algorithm. The presented results give an accuracy over 95% in the determination of the coordinates (x, y) from the expected cell center of mass.
Cite: Martínez Gómez, C., Olmo Fernández, A., Huertas Sánchez, G., Pérez García, P., Maldonado Jacobi, A. y Yúfera García, A. (2017). A Tracking Algorithm For Cell Motility Assays in CMOS Systems. En EMBC 2017: 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (837-840), Seogwipo, South Korea: IEEE Computer Society.
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Format: PDF

URI: https://hdl.handle.net/11441/76109

DOI: 10.1109/EMBC.2017.8036954

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