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Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.

Opened Access Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.

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Autor: Pachón Ibáñez, María Eugenia
Labrador Herrera, Gema
Cebrero Cangueiro, Tania
Díaz, Caridad
Pascual Hernández, Álvaro
Conejo Gonzalo, Mª Carmen
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 2018
Publicado en: Frontiers in Microbiology, 9 (912), 1-9.
Tipo de documento: Artículo
Resumen: Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of studies to evaluate in vivo the efficacy of combinations therapies. The bactericidal activity of colistin, rifampin, and its combination was studied (time-kill curves) against four clonally unrelated clinical isolates of CP-Kp, producing VIM-1, VIM-1 plus DHA-1(acquired AmpC β-lactamase), OXA-48 plus CTX-M-15 (extended spectrum β-lactamase) and KPC-3, respectively, with colistin MICs of 0.5, 64, 0.5, and 32 mg/L, respectively. The efficacies of antimicrobials in monotherapy and in combination were tested in a murine peritoneal sepsis model, against all the CP-Kp. Their efficacies were tested in the pneumonia model against the OXA-48 plus CTX-M-15 producers. The development of colistin-resistance was analyzed for the colistin-susceptible strains in vitro and in vivo. In vitro, colistin plus rifampin was synergistic against all the strains at 24 h. In vivo, compared to ...
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Cita: Pachón Ibáñez, M.E., Labrador Herrera, G., Cebrero Cangueiro, T., Díaz, C., Pascual Hernández, Á. y Conejo Gonzalo, M.C. (2018). Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.. Frontiers in Microbiology, 9 (912), 1-9.
Tamaño: 676.4Kb
Formato: PDF

URI: https://hdl.handle.net/11441/75793

DOI: 10.3389/fmicb.2018.00912

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