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Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions

Opened Access Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions

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Autor: Martínez, Álvaro
Ortiz Mellet, Carmen
García Fernández, José Manuel
Departamento: Universidad de Sevilla. Departamento de Química orgánica
Fecha: 2013
Publicado en: Chemical Society Reviews, 42, 4746-4773.
Tipo de documento: Artículo
Resumen: Covalent attachment of biorecognizable sugar ligands in several copies at precise positions of cyclomaltooligosaccharide (cyclodextrin, CD) macrocycles has proven to be an extremely flexible strategy to build multivalent conjugates. The commercial availability of the native CDs in three different sizes, their axial symmetry and the possibility of position- and face-selective functionalization allow a strict control of the valency and spatial orientation of the recognition motifs (glycotopes) in low, medium, high and hyperbranched glycoclusters, including glycodendrimer-CD hybrids. >Click-type> ligation chemistries, including copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC), thiol-ene coupling or thiourea-forming reactions, have been implemented to warrant full homogeneity of the adducts. The incorporation of different glycotopes to investigate multivalent interactions in heterogeneous environments has also been accomplished. Not surprisingly, multivalent CD conjugates have been,...
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Cita: Martínez, Á., Ortiz Mellet, C. y García Fernández, J.M. (2013). Cyclodextrin-based multivalent glycodisplays: Covalent and supramolecular conjugates to assess carbohydrate-protein interactions. Chemical Society Reviews, 42, 4746-4773.
Tamaño: 12.31Mb
Formato: PDF

URI: https://hdl.handle.net/11441/70416

DOI: 10.1039/c2cs35424a

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