Repositorio de producción científica de la Universidad de Sevilla

RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions

Opened Access RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Cruz Gallardo, Isabel
Aroca Aguilar, Ángeles
Persson, Cecilia
Karlsson, B. Göran
Díaz Moreno, Irene
Fecha: 2013
Publicado en: Journal of Biological Chemistry, 288, 25986-25994.
Tipo de documento: Artículo
Resumen: Background: T-cell intracellular antigen- 1(TIA-1) is a key DNA/RNA binding protein in RNA metabolism. Results: The binding of TIA-1 RRM3 domain (isolated or fused to RRM2) to RNA is affected by pH changes. Conclusion: The pH-dependence of RRM3/RNA interaction may have a significant effect in the overall TIA-1 function. Significance: Unveiling the auxiliary role of RRM3 in RNA recognition sheds light on the TIA-1 function between cell compartments changes due to the protonation / deprotonation of TIA-1 RRM3 histidine residues. The auxiliary role of the Cterminal RRM3 domain in TIA-1 RNA recognition is poorly understood and this work provides an insight into its binding mechanisms
Cita: Cruz Gallardo, I., Aroca Aguilar, Á., Persson, C., Karlsson, B.G. y Díaz Moreno, I. (2013). RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions. Journal of Biological Chemistry, 288, 25986-25994.
Tamaño: 3.521Mb
Formato: PDF

URI: https://hdl.handle.net/11441/70292

DOI: 10.1074/jbc.M113.489070

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones