dc.creator | Cruz Gallardo, Isabel | es |
dc.creator | Aroca Aguilar, Ángeles | es |
dc.creator | Persson, Cecilia | es |
dc.creator | Karlsson, B. Göran | es |
dc.creator | Díaz Moreno, Irene | es |
dc.date.accessioned | 2018-02-14T15:18:00Z | |
dc.date.available | 2018-02-14T15:18:00Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Cruz Gallardo, I., Aroca Aguilar, Á., Persson, C., Karlsson, B.G. y Díaz Moreno, I. (2013). RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions. Journal of Biological Chemistry, 288, 25986-25994. | |
dc.identifier.issn | 0021-9258 (impreso) | es |
dc.identifier.issn | 1083-351X (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/70292 | |
dc.description.abstract | Background: T-cell intracellular antigen- 1(TIA-1) is a key DNA/RNA binding protein in RNA metabolism. Results: The binding of TIA-1 RRM3 domain (isolated or fused to RRM2) to RNA is affected by pH changes. Conclusion: The pH-dependence of RRM3/RNA interaction may have a significant effect in the overall TIA-1 function. Significance: Unveiling the auxiliary role of RRM3 in RNA recognition sheds light on the TIA-1 function between cell compartments changes due to the protonation / deprotonation of TIA-1 RRM3 histidine residues. The auxiliary role of the Cterminal RRM3 domain in TIA-1 RNA recognition is poorly understood and this work provides an insight into its binding mechanisms | es |
dc.description.sponsorship | Junta de Andalucía P07-CVI-02896, BIO198 | es |
dc.description.sponsorship | European Union FP7/2007-2013- 261863 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Biochemistry and Molecular Biology | es |
dc.relation.ispartof | Journal of Biological Chemistry, 288, 25986-25994. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | DNA/RNA binding protein (D/RBP) | es |
dc.subject | PH-dependence | es |
dc.subject | NMR | es |
dc.subject | RNA recognition motif (RRM) | es |
dc.subject | T-cell intracellular antigen-1 (TIA-1) | es |
dc.title | RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.projectID | P07-CVI-02896 | es |
dc.relation.projectID | BIO198 | es |
dc.relation.projectID | FP7/2007-2013- 261863 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1074/jbc.M113.489070 | es |
dc.identifier.doi | 10.1074/jbc.M113.489070 | es |
idus.format.extent | 19 p. | es |
dc.journaltitle | Journal of Biological Chemistry | es |
dc.publication.volumen | 288 | es |
dc.publication.initialPage | 25986 | es |
dc.publication.endPage | 25994 | es |
dc.contributor.funder | Junta de Andalucía | |
dc.contributor.funder | European Union (UE). FP7 | |