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Identification of a promising multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

Opened Access Identification of a promising multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

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Autor: Varga, Norbert
Ribeiro Viana, Renato Márcio
Berzi, Angela
Ramdasi, Rasika
Daghetti, Anna
Vettoretti, Gerolamo
Amara, Ali
ClericI, Mario
Rojo Marcos, Francisco Javier
Fieschi, Franck
Bernardi, Anna
Fecha: 2014
Publicado en: Biomaterials, 35 (13), 4175-4184.
Tipo de documento: Artículo
Resumen: DC-SIGN is a C-type lectin receptor on antigen presenting cells (dendritic cells) which has an important role in some viral infection, notably by HIV and Dengue virus (DV). Multivalent presentation of carbohydrates on dendrimeric scaffolds has been shown to inhibit DC-SIGN binding to HIV envelope glycoprotein gp120, thus blocking viral entry. This approach has interesting potential applications for infection prophylaxis. In an effort to develop high affinity inhibitors of DC-SIGN mediated viral entry, we have synthesized a group of glycodendrimers of different valency that bear different carbohydrates or glycomimetic DC-SIGN ligands and have studied their DC-SIGN binding activity and antiviral properties both in an HIV and a Dengue infection model. Surface Plasmon Resonance (SPR) competition studies have demonstrated that the materials obtained bind efficiently to DC-SIGN with IC50s in the μm range, which depend on the nature of the ligand and on the valency of the scaffold. In partic...
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Cita: Varga, N., Ribeiro Viana, R., Berzi, A., Ramdasi, R., Daghetti, A., Vettoretti, G.,...,Bernardi, A. (2014). Identification of a promising multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus. Biomaterials, 35 (13), 4175-4184.
Tamaño: 1.840Mb
Formato: PDF

URI: https://hdl.handle.net/11441/69933

DOI: 10.1016/j.biomaterials.2014.01.014

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