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Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders

 

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Opened Access Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders
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Author: Chorny, Alejo
Gonzalez-Rey, Elena
Fernandez-Martin, Amelia
Pozo Pérez, David
Ganea, Doina
Delgado, Mario
Department: Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Date: 2005
Document type: Article
Abstract: The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune-response-inducing T cell reactivity, dendritic cells (DCs) play an important role in maintaining peripheral tolerance through the induction/activation of regulatory T cells (Tr). The possibility to generate tolerogenic DCs opens new therapeutic perspectives in autoimmune/inflammatory diseases. Therefore, the characterization of the endogenous factors that contribute to the development of tolerogenic DCs is highly relevant. In this study, we report on the use of the known immunosuppressive neuropeptide, the vasoactive intestinal peptide, as a new approach to induce tolerogenic DCs with capacity to generate Tr cells, to restore tolerance in vivo, and to reduce the progression of rheumatoid arthritis and experimental autoimmune encephalomyelitis. © 2005 by The National Academy of Sciences of the USA.
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URI: https://hdl.handle.net/11441/69626

DOI: 10.1073/pnas.0504484102

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