dc.creator | García Mauriño, Sofía M. | es |
dc.creator | Rivero Rodríguez, Francisco | es |
dc.creator | Velázquez Cruz, Alejandro | es |
dc.creator | Hernández Vellisca, Marian | es |
dc.creator | Díaz Quintana, Antonio Jesús | es |
dc.creator | Rosa Acosta, Miguel Ángel de la | es |
dc.creator | Díaz Moreno, Irene | es |
dc.date.accessioned | 2017-11-14T16:50:07Z | |
dc.date.available | 2017-11-14T16:50:07Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | García Mauriño, S.M., Rivero Rodríguez, F., Velázquez Cruz, A., Hernández Vellisca, M., Díaz Quintana, A.J., Rosa Acosta, M.Á.d.l. y Díaz Moreno, I. (2017). RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate. Frontiers in Molecular Biosciences, 4 (71), 1-8. | |
dc.identifier.issn | 2296-889X | es |
dc.identifier.uri | http://hdl.handle.net/11441/66027 | |
dc.description.abstract | mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3′ untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control. Furthermore, ARE recognition can be self-regulated by several factors that lead to the prevalence of one RBP over another. Consequently, we examine the factors that modulate the dynamics of those protein-RNA transient interactions to better understand the final consequences of the regulation mediated by ARE-RBPs. For instance, factors controlling the RBP isoforms, their conformational state or their post-translational modifications (PTMs) can strongly determine the fate of the protein-RNA complexes. Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned regulation is a challenge for future research and requires the integration of all the available structural and functional data by in vivo, in vitro and in silico approaches. | es |
dc.description.sponsorship | España, Ministerio de Economía y Competitividad BFU2015-71017-P | es |
dc.description.sponsorship | España, Ministerio de Educación, Cultura y Deporte FPU013/04373, FPU016/01513 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Molecular Biosciences, 4 (71), 1-8. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | mRNA fate | es |
dc.subject | post-transcriptional regulation | es |
dc.subject | RNA binding proteins | es |
dc.subject | stability | es |
dc.subject | translation | es |
dc.title | RNA Binding Protein Regulation and Cross-Talk in the Control of AU-rich mRNA Fate | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Vegetal y Ecología | es |
dc.relation.projectID | BFU2015-71017-P | es |
dc.relation.projectID | FPU013/04373 | es |
dc.relation.projectID | FPU016/01513 | es |
dc.relation.publisherversion | http://dx.doi.org/ 10.3389/fmolb.2017.00071 | es |
dc.identifier.doi | 10.3389/fmolb.2017.00071 | es |
idus.format.extent | 9 p. | es |
dc.journaltitle | Frontiers in Molecular Biosciences | es |
dc.publication.volumen | 4 | es |
dc.publication.issue | 71 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 8 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (MECD). España | |