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Excitability is increased in hippocampal CA1 pyramidal cells of Fmr1 knockout mice

Opened Access Excitability is increased in hippocampal CA1 pyramidal cells of Fmr1 knockout mice

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Autor: Torres Ruiz, Blas
Beltrán Matas, Pablo
Luque Laó, María Ángeles
Herrero Rama, Luis Jacinto
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2017
Publicado en: Plos One, 12 (9), 1-18.
Tipo de documento: Artículo
Resumen: Fragile X syndrome (FXS) is caused by a failure of neuronal cells to express the gene encoding the fragile mental retardation protein (FMRP). Clinical features of the syndrome include intellectual disability, learning impairment, hyperactivity, seizures and anxiety. Fmr1 knockout (KO) mice do not express FMRP and, as a result, reproduce some FXS behavioral abnormalities. While intrinsic and synaptic properties of excitatory cells in various part of the brain have been studied in Fmr1 KO mice, a thorough analysis of action potential characteristics and input-output function of CA1 pyramidal cells in this model is lacking. With a view to determining the effects of the absence of FMRP on cell excitability, we studied rheobase, action potential duration, firing frequency-current intensity relationship and action potential after-hyperpolarization (AHP) in CA1 pyramidal cells of the hippocampus of wild type (WT) and Fmr1 KO male mice. Brain slices were prepared from 8- to 12-week-old mice a...
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Cita: Torres Ruiz, B., Beltrán Matas, P., Luque Laó, M.Á. y Herrero Rama, L.J. (2017). Excitability is increased in hippocampal CA1 pyramidal cells of Fmr1 knockout mice. Plos One, 12 (9), 1-18.
Tamaño: 3.575Mb
Formato: PDF

URI: http://hdl.handle.net/11441/65870

DOI: 10.1371/journal.pone.0185067

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