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Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations

 

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Opened Access Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations
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Author: Martínez Martínez, Luis
Pascual Hernández, Álvaro
Conejo Gonzalo, Mª Carmen
Picabea de la Peña, Leandro
Perea Pérez, Evelio José
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 1999-02-01
Published in: Antimicrobial Agents and Chemotherapy, 43 (2), 397-399.
Document type: Article
Abstract: The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted from siliconized latex urinary catheters (SLUCs). SLUCs did not inactivate imipenem or increase β- lactamase activity. The outer membrane of P. aeruginosa HUS-3 grown in the presence of eluate lacked an OprD-like protein and expressed a new 50-kDa protein. The decreased activity of imipenem against P. aeruginosa in the presence of SLUCs is related to the loss of an OprD-like protein and the expression of a new outer membrane protein.
Cite: Martínez Martínez, L., Pascual Hernández, Á., Conejo Gonzalo, M.C., Picabea, L. y Perea Pérez, E.J. (1999). Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations. Antimicrobial Agents and Chemotherapy, 43 (2), 397-399.
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URI: http://hdl.handle.net/11441/65018

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