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Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes

 

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Opened Access Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes
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Author: García Luque, Isabel
Ballesta, Sofía
Murillo del Castillo, Concepción
Perea Pérez, Evelio José
Pascual Hernández, Álvaro
Department: Universidad de Sevilla. Departamento de Microbiología
Universidad de Sevilla. Departamento de Estomatología
Date: 2006-09-01
Published in: Antimicrobial Agents and Chemotherapy, 50 (9), 3173-3174.
Document type: Article
Abstract: The intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes have been evaluated. DX-619 reached intracellular concentrations 10 times higher than the extracellular concentrations reached. Uptake was rapid, reversible, nonsaturable, and affected by environmental temperature, some metabolic inhibitors, and a soluble membrane activator. DX-619 showed intracellular activity against Staphylococcus aureus.
Cite: García Luque, I., Ballesta, S., Murillo del Castillo, C., Perea Pérez, E.J. y Pascual Hernández, Á. (2006). Intracellular penetration and activity of DX-619 in human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy, 50 (9), 3173-3174.
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URI: http://hdl.handle.net/11441/65016

DOI: 10.1128/AAC.00427-06

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