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Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells

Opened Access Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells
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Autor: Pascual Hernández, Álvaro
Ballesta Mudarra, Sofía
Perea Pérez, Evelio José
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 1997-02-01
Publicado en: Antimicrobial Agents and Chemotherapy, 41 (2), 274-277.
Tipo de documento: Artículo
Resumen: The penetration of trovafloxacin into human polymorphonuclear leukocytes (PMNs), human peritoneal macrophages, and tissue-cultured epithelial cells (McCoy cells) was evaluated. The cellular concentration to extracellular concentration (C/E) ratios of trovafloxacin were greater than 9 for extracellular concentrations ranging from 0.5 to 25 μg/ml. The uptake of trovafloxacin by PMNs was rapid, reversible, nonsaturable, not energy dependent, and significantly increased at pH 6. The C/E ratios of trovafloxacin were not affected by cell viability but were significantly increased at 4°C. Ingestion of opsonized zymosan, but not opsonized Staphylococcus aureus, significantly increased the amount of PMN-associated trovafloxacin. This agent at concentrations of 0.5 and 1 μg/ml induced a greater reduction in the survival of intracellular S. aureus in PMNs than ciprofloxacin and ofloxacin. It was concluded that trovafloxacin reaches concentrations within phagocytic and nonphagocytic cells several...
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Cita: Pascual Hernández, Á., Ballesta Mudarra, S. y Perea Pérez, E.J. (1997). Uptake and intracellular activity of trovafloxacin in human phagocytes and tissue-cultured epithelial cells. Antimicrobial Agents and Chemotherapy, 41 (2), 274-277.
Tamaño: 208.5Kb
Formato: PDF

URI: http://hdl.handle.net/11441/65009

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