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Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes
| dc.creator | García Luque, Isabel | es |
| dc.creator | Pascual Hernández, Álvaro | es |
| dc.creator | Joyanes, Providencia | es |
| dc.creator | Perea Pérez, Evelio José | es |
| dc.date.accessioned | 2017-09-28T17:22:11Z | |
| dc.date.available | 2017-09-28T17:22:11Z | |
| dc.date.issued | 2000-11-09 | |
| dc.identifier.citation | García Luque, I., Pascual Hernández, Á., Joyanes, P. y Perea Pérez, E.J. (2000). Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy, 44 (11), 3193-3195. | |
| dc.identifier.issn | 0066-4804 (impreso) | es |
| dc.identifier.issn | 1098-6596 (electrónico) | es |
| dc.identifier.uri | http://hdl.handle.net/11441/64865 | |
| dc.description.abstract | The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus. | es |
| dc.format | application/pdf | es |
| dc.language.iso | eng | es |
| dc.publisher | American Society for Microbiology | es |
| dc.relation.ispartof | Antimicrobial Agents and Chemotherapy, 44 (11), 3193-3195. | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.title | Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes | es |
| dc.type | info:eu-repo/semantics/article | es |
| dcterms.identifier | https://ror.org/03yxnpp24 | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | es |
| dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es |
| dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
| dc.date.embargoEndDate | 2019 | |
| dc.relation.publisherversion | http://dx.doi.org/10.1128/AAC.44.11.3193-3195.2000 | es |
| dc.identifier.doi | 10.1128/AAC.44.11.3193-3195.2000 | es |
| idus.format.extent | 3 p. | es |
| dc.journaltitle | Antimicrobial Agents and Chemotherapy | es |
| dc.publication.volumen | 44 | es |
| dc.publication.issue | 11 | es |
| dc.publication.initialPage | 3193 | es |
| dc.publication.endPage | 3195 | es |
| Ficheros | Tamaño | Formato | Ver | Descripción |
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| Intracellular penetration and ... | 76.95Kb | 
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