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Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes

Acceso restringido Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes

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Autor: García Luque, Isabel
Pascual Hernández, Álvaro
Joyanes, Providencia
Perea Pérez, Evelio José
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 2000-11-09
Publicado en: Antimicrobial Agents and Chemotherapy, 44 (11), 3193-3195.
Tipo de documento: Artículo
Resumen: The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.
Cita: García Luque, I., Pascual Hernández, Á., Joyanes, P. y Perea Pérez, E.J. (2000). Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy, 44 (11), 3193-3195.
Tamaño: 76.95Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64865

DOI: 10.1128/AAC.44.11.3193-3195.2000

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