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Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes

 

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Acceso restringido Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes
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Author: García Luque, Isabel
Pascual Hernández, Álvaro
Joyanes, Providencia
Perea Pérez, Evelio José
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2000-11-09
Published in: Antimicrobial Agents and Chemotherapy, 44 (11), 3193-3195.
Document type: Article
Abstract: The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.
Cite: García Luque, I., Pascual Hernández, Á., Joyanes, P. y Perea Pérez, E.J. (2000). Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes. Antimicrobial Agents and Chemotherapy, 44 (11), 3193-3195.
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URI: http://hdl.handle.net/11441/64865

DOI: 10.1128/AAC.44.11.3193-3195.2000

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