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Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem

Opened Access Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem

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Autor: Conejo Gonzalo, Mª Carmen
Pascual Hernández, Álvaro
Otero, Jesús
Ortega, Adriana
Bartolomé, Rosa M.
Bou, Germán
Fernández Martínez, Marta
González López, Juan José
Departamento: Universidad de Sevilla. Departamento de Microbiología
Fecha: 2015-06-01
Publicado en: Antimicrobial Agents and Chemotherapy, 59 (6), 3406-3412.
Tipo de documento: Artículo
Resumen: The aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by describing the prevalence, dissemination, and geographic distribution of CPE clones, and their population structure and antibiotic susceptibility. From February 2013 to May 2013, 83 hospitals (about 40,000 hospital beds) prospectively collected nonduplicate Enterobacteriaceae using the screening cutoff recommended by EUCAST. Carbapenemase characterization was performed by phenotypic methods and confirmed by PCR and sequencing. Multilocus sequencing types (MLST) were determined for Klebsiella pneumoniae and Escherichia coli. A total of 702 Enterobacteriaceae isolates met the inclusion criteria; 379 (54%) were CPE. OXA-48 (71.5%) and VIM-1 (25.3%) were the most frequent carbapenemases, and K. pneumoniae (74.4%), Enterobacter cloacae (10.3%), and E. coli (8.4%) were the species most affected. Susceptibility to colistin, amikacin, and meropenem was 95.5%, 81.3%, and 74...
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Cita: Conejo Gonzalo, M.C., Pascual Hernández, Á., Otero, J., Ortega, A., Bartolomé, R.M., Bou, G.,...,González López, J.J. (2015). Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem. Antimicrobial Agents and Chemotherapy, 59 (6), 3406-3412.
Tamaño: 805.0Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64854

DOI: 10.1128/AAC.00086-15

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