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Urinary tract physiological conditions promote ciprofloxacin resistance in low-level-quinolone-resistant Escherichia coli

Opened Access Urinary tract physiological conditions promote ciprofloxacin resistance in low-level-quinolone-resistant Escherichia coli

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Autor: Martín Gutiérrez, Guillermo
Rodríguez Beltrán, Jerónimo
Rodríguez Martínez, José Manuel
Costas, Coloma
Aznar Martín, Javier
Pascual Hernández, Álvaro
Blázquez, Jesús
Fecha: 2016-07-01
Publicado en: Antimicrobial Agents and Chemotherapy, 60 (7), 4252-4258.
Tipo de documento: Artículo
Resumen: Escherichia coli isolates carrying chromosomally encoded low-level-quinolone-resistant (LLQR) determinants are frequently found in urinary tract infections (UTIs). LLQR mutations are considered the first step in the evolutionary pathway producing high-level fluoroquinolone resistance. Therefore, their evolution and dissemination might influence the outcome of fluoroquinolone treatments of UTI. Previous studies support the notion that low urine pH decreases susceptibility to ciprofloxacin (CIP) in E. coli. However, the effect of the urinary tract physiological parameters on the activity of ciprofloxacin against LLQR E. coli strains has received little attention. We have studied the activity of ciprofloxacin under physiological urinary tract conditions against a set of well-characterized isogenic E. coli derivatives carrying the most prevalent chromosomal mutations (ΔmarR, gyrA-S83L, gyrA-D87N, and parC-S80R and some combinations). The results presented here demonstrate that all the LLQ...
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Cita: Martín Gutiérrez, G., Rodríguez Beltrán, J., Rodríguez Martínez, J.M., Costas, C., Aznar Martín, J., Pascual Hernández, Á. y Blázquez, J. (2016). Urinary tract physiological conditions promote ciprofloxacin resistance in low-level-quinolone-resistant Escherichia coli. Antimicrobial Agents and Chemotherapy, 60 (7), 4252-4258.
Tamaño: 639.3Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64848

DOI: 10.1128/AAC.00602-16

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