Repositorio de producción científica de la Universidad de Sevilla

Bile-induced peptidoglycan remodelling in Salmonella enterica

Opened Access Bile-induced peptidoglycan remodelling in Salmonella enterica

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Hernández Piñero, Sara Belén
Cava, Felipe
Pucciarelli, María Graciela
García del Portillo, Francisco
Pedro, Miguel Ángel de
Casadesús Pursals, Josep
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2015
Publicado en: Environmental Microbiology, 17 (4), 1081-1089.
Tipo de documento: Artículo
Resumen: Changes in the peptidoglycan (PG) structure of Salmonella enterica are detected in the presence of a sublethal concentration of sodium deoxycholate (DOC): (i) lower proportions of Braun lipoprotein (Lpp)-bound muropeptides; (ii) reduced levels of muropeptides cross-linked by L(meso)-diaminopimelyl-D(meso)-diaminopimelic acid (L-D) peptide bridges (3-3 cross-links). Similar structural changes are found in S.enterica cultures adapted to grow in the presence of a lethal concentration of DOC, suggesting that reduced anchoring of Braun protein to PG and low occurrence of 3-3 cross-links may increase S.enterica resistance to bile. This view is further supported by additional observations: (i) A triple mutant lacking L,D-transpeptidases YbiS, ErfK, and YcfS, which does not contain Lpp anchored to PG, is hyper-resistant to bile; (ii) enhanced 3-3 cross-linking upon overexpression of YnhG transpeptidase causes a decrease in bile resistance. These observations suggest that remodelling of the ce...
[Ver más]
Cita: Hernández Piñero, S.B., Cava, F., Pucciarelli, M.G., García del Portillo, F., Pedro, M.Á.d. y Casadesús Pursals, J. (2015). Bile-induced peptidoglycan remodelling in Salmonella enterica. Environmental Microbiology, 17 (4), 1081-1089.
Tamaño: 224.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64317

DOI: 10.1111/1462-2920.12491

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones