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Non‐Canonical Replication Initiation: You’re Fired!

Opened Access Non‐Canonical Replication Initiation: You’re Fired!

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Autor: Ravoitytė, Bazilė
Wellinger, Ralf Erik
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2017
Publicado en: Genes, 8 (2,54), 1-17.
Tipo de documento: Artículo
Resumen: The division of prokaryotic and eukaryotic cells produces two cells that inherit a perfect copy of the genetic material originally derived from the mother cell. The initiation of canonical DNA replication must be coordinated to the cell cycle to ensure the accuracy of genome duplication. Controlled replication initiation depends on a complex interplay of cis‐acting DNA sequences, the so‐called origins of replication (ori), with trans‐acting factors involved in the onset of DNA synthesis. The interplay of cis‐acting elements and trans‐acting factors ensures that cells initiate replication at sequence‐specific sites only once, and in a timely order, to avoid chromosomal endoreplication. However, chromosome breakage and excessive RNA:DNA hybrid formation can cause breakinduced (BIR) or transcription‐initiated replication (TIR), respectively. These non‐canonical replication events are expected to affect eukaryotic genome function and maintenance, and could be important for genome evolutio...
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Cita: Ravoitytė, B. y Wellinger, R.E. (2017). Non‐Canonical Replication Initiation: You’re Fired!. Genes, 8 (2,54), 1-17.
Tamaño: 617.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/64040

DOI: doi:10.3390/genes8020054

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