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Role of the RecBCD recombination pathway in Salmonella virulence

Opened Access Role of the RecBCD recombination pathway in Salmonella virulence

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Autor: A. Cano, David
Pucciarelli, María Graciela
García del Portillo, Francisco
Casadesús Pursals, Josep
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2002
Publicado en: Journal of Bacteriology, 184 (2), 592-595.
Tipo de documento: Artículo
Resumen: Mutants of Salmonella enterica lacking the RecBC function are avirulent in mice and unable to grow inside macrophages (N. A. Buchmeier, C. J. Lipps, M. Y. H. So, and F. Heffron, Mol. Microbiol. 7:933-936, 1993). The virulence-related defects of RecBC- mutants are not suppressed by sbcB and sbcCD mutations, indicating that activation of the RecF recombination pathway cannot replace the virulence-related function(s) of RecBCD. Functions of the RecF pathway such as RecJ and RecF are not required for virulence. Since the RecBCD pathway, but not the RecF pathway, is known to participate in the repair of double-strand breaks produced during DNA replication, we propose that systemic infection by S. enterica may require RecBCD-mediated recombinational repair to prime DNA replication inside phagocytes. Mutants lacking both RecD and RecJ are also attenuated in mice and are unable to proliferate in macrophages, suggesting that exonucleases V and IX provide alternative functions for RecBCD-mediat...
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Cita: A. Cano, D., Pucciarelli, M.G., García del Portillo, F. y Casadesús Pursals, J. (2002). Role of the RecBCD recombination pathway in Salmonella virulence. Journal of Bacteriology, 184 (2), 592-595.
Tamaño: 123.1Kb
Formato: PDF

URI: http://hdl.handle.net/11441/63356

DOI: 10.1128/JB.184.2.592–595.2002

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