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Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost

 

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Opened Access Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost
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Author: Cauce, Alejandro
Briales, Alejandra
Rodríguez Rojas, Alexandro
Costas, Coloma
Pascual Hernández, Álvaro
Blázquez, Jesús
Department: Universidad de Sevilla. Departamento de Microbiología
Date: 2012-05-01
Published in: Antimicrobial Agents and Chemotherapy, 56 (5), 2767-2769.
Document type: Article
Abstract: To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a complete set of 5,272 plasmid-expressed open reading frames of Escherichia coli (ASKA collection) was performed. Major results are that (i) no clinical level of resistance is achieved by overexpressing chromosomal genes, except murA; (ii) this level is reached at a low fitness cost; and (iii) this cost is much lower than that imposed by other mutations conferring fosfomycin resistance.
Cite: Cauce, A., Briales, A., Rodríguez Rojas, A., Costas, C., Pascual Hernández, Á. y Blázquez, J. (2012). Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost. Antimicrobial Agents and Chemotherapy, 56 (5), 2767-2769.
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URI: http://hdl.handle.net/11441/63338

DOI: 10.1128/AAC.06122-11

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