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DNA adenine methylation regulates virulence gene expression in Salmonella enterica serovar typhimurium

Opened Access DNA adenine methylation regulates virulence gene expression in Salmonella enterica serovar typhimurium

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Autor: Balbontín Soria, Roberto
Rowley, Gary
Pucciarelli, María Graciela
López Garrido, Javier
Wormstone, Yvette
Lucchini, Sacha
García del Portillo, Francisco
Hinton, Jay C.
Casadesús Pursals, Josep
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2006
Publicado en: Journal of Bacteriology, 188 (23), 8160-8168.
Tipo de documento: Artículo
Resumen: Transcriptomic analyses during growth in Luria-Bertani medium were performed in strain SL1344 of Salmonella enterica serovar Typhimurium and in two isogenic derivatives lacking Dam methylase. More genes were repressed than were activated by Dam methylation (139 versus 37). Key genes that were differentially regulated by Dam methylation were verified independently. The largest classes of Dam-repressed genes included genes belonging to the SOS regulon, as previously described in Escherichia coli, and genes of the SOS-inducible Salmonella prophages ST64B, Gifsy-1, and Fels-2. Dam-dependent virulence-related genes were also identified. Invasion genes in pathogenicity island SPI-1 were activated by Dam methylation, while the fimbrial operon std was repressed by Dam methylation. Certain Magellan genes were repressed by Dam methylation, and Dam- mutants of S. enterica showed reduced motility. Altered expression patterns in the absence of Dam methylation were also found for the chemotaxis gen...
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Cita: Balbontín Soria, R., Rowley, G., Pucciarelli, M.G., López Garrido, J., Wormstone, Y., Lucchini, S.,...,Casadesús Pursals, J. (2006). DNA adenine methylation regulates virulence gene expression in Salmonella enterica serovar typhimurium. Journal of Bacteriology, 188 (23), 8160-8168.
Tamaño: 221.8Kb
Formato: PDF

URI: http://hdl.handle.net/11441/62955

DOI: 10.1128/JB.00847-06

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