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PSA-NCAM is expressed in immature, but not recently generated, neurons in the adult cat cerebral cortex layer II

Opened Access PSA-NCAM is expressed in immature, but not recently generated, neurons in the adult cat cerebral cortex layer II

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Autor: Varea Varea, Emilio
Belles, María
Vidueira, Salvador
Blasco Ibáñez, José Miguel
Crespo, Carlos
Pastor Loro, Ángel Manuel
Nacher, Juan
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2011
Publicado en: Frontiers in Neuroscience, FEB, 17-.
Tipo de documento: Artículo
Resumen: Neuronal production persists during adulthood in the dentate gyrus and the olfactory bulb, where substantial numbers of immature neurons can be found. These cells can also be found in the paleocortex layer II of adult rodents, but in this case most of them have been generated during embryogenesis. Recent reports have described the presence of similar cells, with a wider distribution, in the cerebral cortex of adult cats and primates and have suggested that they may develop into interneurons. The objective of this study is to verify this hypothesis and to explore the origin of these immature neurons in adult cats. We have analyzed their distribution using immunohistochemical analysis of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) and their phenotype using markers of mature neurons and different interneuronal populations. Additionally, we have explored the origin of these cells administering 5′bromodeoxyuridine (5′BrdU) during adulthood. Immature neurons were...
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Cita: Varea Varea, E., Belles, M., Vidueira, S., Blasco Ibáñez, J.M., Crespo, C., Pastor Loro, Á.M. y Nacher, J. (2011). PSA-NCAM is expressed in immature, but not recently generated, neurons in the adult cat cerebral cortex layer II. Frontiers in Neuroscience, FEB, 17-.
Tamaño: 2.966Mb
Formato: PDF

URI: http://hdl.handle.net/11441/62625

DOI: 10.3389/fnins.2011.00017

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