Repositorio de producción científica de la Universidad de Sevilla

Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion

Opened Access Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: Rivera Chávez, Fabián
López, Christopher A.
García Pastor, Lucía
Chávez Arroyo, Alfredo
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2016
Publicado en: Mbio, 7 (4)
Tipo de documento: Artículo
Resumen: Salmonella enterica serovar Typhimurium can cross the epithelial barrier using either the invasion-associated type III secretion system (T3SS-1) or a T3SS-1-independent mechanism that remains poorly characterized. Here we show that flagellum-mediated motility supported a T3SS-1-independent pathway for entering ileal Peyer’s patches in the mouse model. Flagellum-dependent invasion of Peyer’s patches required energy taxis toward nitrate, which was mediated by the methyl-accepting chemotaxis protein (MCP) Tsr. Generation of nitrate in the intestinal lumen required inducible nitric oxide synthase (iNOS), which was synthesized constitutively in the mucosa of the terminal ileum but not in the jejunum, duodenum, or cecum. Tsr-mediated invasion of ileal Peyer’s patches was abrogated in mice deficient for Nos2, the gene encoding iNOS. We conclude that Tsr-mediated energy taxis enables S. Typhimurium to migrate toward the intestinal epithelium by sensing host-derived nitrate, thereby contributi...
[Ver más]
Cita: Rivera Chávez, F., López, C.A., García Pastor, L. y Chávez Arroyo, A. (2016). Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion. Mbio, 7 (4)
Tamaño: 1.775Mb
Formato: PDF

URI: http://hdl.handle.net/11441/60925

DOI: 10.1128/mBio.00960-16

Ver versión del editor

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones