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Epigenetic Control of Salmonella enterica O-Antigen Chain Length: A Tradeoff between Virulence and Bacteriophage Resistance

Opened Access Epigenetic Control of Salmonella enterica O-Antigen Chain Length: A Tradeoff between Virulence and Bacteriophage Resistance

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Autor: Cota García, Ignacio
Sánchez Romero, Maria Antonia
Hernández Piñero, Sara Belén
Pucciarelli, María Graciela
García del Portillo, Francisco
Casadesús Pursals, Josep
Departamento: Universidad de Sevilla. Departamento de Genética
Fecha: 2015
Publicado en: Plos Genetics, 11 (11), 1-18.
Tipo de documento: Artículo
Resumen: The Salmonella enterica opvAB operon is a horizontally-acquired locus that undergoes phase variation under Dam methylation control. The OpvA and OpvB proteins form intertwining ribbons in the inner membrane. Synthesis of OpvA and OpvB alters lipopolysaccharide O-antigen chain length and confers resistance to bacteriophages 9NA (Siphoviridae), Det7 (Myoviridae), and P22 (Podoviridae). These phages use the O-antigen as receptor. Because opvAB undergoes phase variation, S. enterica cultures contain subpopulations of opvAB OFF and opvAB ON cells. In the presence of a bacteriophage that uses the O-antigen as receptor, the opvAB OFF subpopulation is killed and the opvAB ON subpopulation is selected. Acquisition of phage resistance by phase variation of O-antigen chain length requires a payoff: opvAB expression reduces Salmonella virulence. However, phase variation permits resuscitation of the opvAB OFF subpopulation as soon as phage challenge ceases. Phenotypic heterogeneity generated by op...
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Cita: Cota García, I., Sánchez Romero, M.A., Hernández Piñero, S.B., Pucciarelli, M.G., García del Portillo, F. y Casadesús Pursals, J. (2015). Epigenetic Control of Salmonella enterica O-Antigen Chain Length: A Tradeoff between Virulence and Bacteriophage Resistance. Plos Genetics, 11 (11), 1-18.
Tamaño: 5.704Mb
Formato: PDF

URI: http://hdl.handle.net/11441/60911

DOI: 10.1371/journal.pgen.1005667

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