Opened Access Are there mutator polymerases?
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Author: García Díaz, Miguel
Ruiz Pérez, José Francisco
Juárez, Raquel
Terrados, Gloria
Blanco, Luis
Department: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Date: 2003
Published in: The Scientific World Journal, 3, 422-431.
Document type: Article
Abstract: DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. Some of these polymerases have a very low fidelity and have been suggested to play mutator roles in different processes, like translesion synthesis or somatic hypermutation. The current view of these processes is reviewed, and the current understanding of DNA polymerases and their role as mutator enzymes is discussed
Cite: García Díaz, M., Ruiz Pérez, J.F., Juárez, R.E., Terrados, G. y Blanco, L. (2003). Are there mutator polymerases?. The Scientific World Journal, 3, 422-431.
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