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Molecular and Immunological Characterization of Gluten Proteins Isolated from Oat Cultivars That Differ in Toxicity for Celiac Disease

Opened Access Molecular and Immunological Characterization of Gluten Proteins Isolated from Oat Cultivars That Differ in Toxicity for Celiac Disease

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Autor: Real, Ana
Comino Montilla, Isabel María
Lorenzo, Laura de
Merchán Ignacio, Francisco
Gil Humanes, Javier
Giménez, María J.
López Casado, Miguel Ángel
Torres, Mª Isabel
Cebolla, Ángel
Sousa Martín, Carolina
Barro, Francisco
Pistón, Fernando
Departamento: Universidad de Sevilla. Departamento de Microbiología y Parasitología
Fecha: 2012
Publicado en: PLoS One, 7 (12), e48365-.
Tipo de documento: Artículo
Resumen: A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease (CD). Traditionally, treatment with a GFD has excluded wheat, barley and rye, while the presence of oats is a subject of debate. The most-recent research indicates that some cultivars of oats can be a safe part of a GFD. In order to elucidate the toxicity of the prolamins from oat varieties with low, medium, and high CD toxicity, the avenin genes of these varieties were cloned and sequenced, and their expression quantified throughout the grain development. At the protein level, we have accomplished an exhaustive characterization and quantification of avenins by RP-HPLC and an analysis of immunogenicity of peptides present in prolamins of different oat cultivars. Avenin sequences were classified into three different groups, which have homology with S-rich prolamins of Triticeae. Avenin proteins presented a lower proline content than that of wheat gliadin; this may cont...
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Cita: Real, A., Comino Montilla, I.M., Lorenzo, L.d., Merchán Ignacio, F., Gil Humanes, J., Giménez, M.J.,...,Pistón, F. (2012). Molecular and Immunological Characterization of Gluten Proteins Isolated from Oat Cultivars That Differ in Toxicity for Celiac Disease. PLoS One, 7 (12), e48365-.
Tamaño: 974.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/41960

DOI: http://dx.doi.org/10.1371/journal.pone.0048365

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