NameComino Montilla, Isabel María
DepartmentMicrobiología y Parasitología
Knowledge areaMicrobiología
Professional categoryProfesora Titular de Universidad
E-mailRequest
           
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Transfer of celiac disease-associated immunogenic gluten peptides in breast milk: variability in kinetics of secretion

Ruiz Carnicer, Ángela; Segura Montero, Verónica; Moreno Amador, María de Lourdes; Coronel Rodríguez, Cristóbal; Sousa Martín, Carolina; Comino Montilla, Isabel María (Frontiers Media, 2024)
Background: Exposure to antigens is crucial for child immune system development, aiding disease prevention and promoting ...
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Effect of Aspergillus Niger Prolyl Endopeptidase in Patients with Celiac Disease on a Long-term Gluten-free Diet

Stefanolo, Juan Pablo; Segura Montero, Verónica; Grizzuti, Martina; Heredia Barroso, Abel; Comino Montilla, Isabel María; Costa, Ana Florencia; Puebla, Roberto; Temprano, María Paz; Niveloni, Sonia Isabel; de Diego, Gabriel; Sousa Martín, Carolina; Bai, Julio César (Baishideng Publishing Group Inc, 2024)
BACKGROUND The gluten-free diet (GFD) has limitations, and there is intense research in the development of adjuvant ...
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Rapid Anti-tTG-IgA Screening Test for Early Diagnosis of Celiac Disease in Pediatric Populations

Mendia, Irati; Segura Montero, Verónica; Ruiz Carnicer, Ángela; Coto, Laura; Negrete, María; Long, Joshua C. D.; Comino Montilla, Isabel María; Sousa Martín, Carolina (MDPI, 2023)
A large number of patients with celiac disease (CD) remain undiagnosed because they do not fulfill the criteria for entry ...
Final Degree Project
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Avances en la relación del virus del papiloma humano y el cáncer

López Castro, Ángela María; Comino Montilla, Isabel María (2023)
El virus del papiloma humano (VPH) es un virus de ADN bicatenario que se compone de más de 200 genotipos y está caracterizado ...
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Clinical Utility of Urinary Gluten Immunogenic Peptides in the Follow-up of Patients with Coeliac Disease

Garzón Benavides, Marta; Ruiz Carnicer, Ángela; Segura Montero, Verónica; Fombuena, Blanca; García-Fernández, Francisco-José; Comino Montilla, Isabel María; Argüelles Arias, Federico; Romero Gómez, Manuel; Sousa Martín, Carolina; Pizarro Moreno, Ángeles (Wiley-Blackwell, 2023)
Background: Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD). and its compliance should ...
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Evaluation of the Usefulness of an Automatable Immunoassay for Monitoring Celiac Disease by Quantification of Immunogenic Gluten Peptides in Urine

Segura Montero, Verónica; Ruiz Carnicer, Ángela; Mendía, Irati; Garzón Benavides, Marta; Pizarro, Ángeles E.; Comino Montilla, Isabel María; Sousa Martín, Carolina (MDPI, 2023)
A gluten-free diet (GFD) is currently the only treatment available for patients with celiac disease (CD). However, adherence ...
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A Highly Sensitive Method for the Detection of Hydrolyzed Gluten in Beer Samples Using LFIA

Segura Montero, Verónica; Siglez, Miguel Ángel; Ruiz Carnicer, Ángela; Martín Cabrejas, Izaskun; van der Hofstadt, María; Mellado Durán, María Encarnación; Comino Montilla, Isabel María; Sousa Martín, Carolina (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Most gluten analysis methods have been developed to detect intact gluten, but they have shown limitations in certain foods ...
Chapter of Book
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Celiac Disease, Management, and Follow-Up

Ruiz Carnicer, Ángela; Segura Montero, Verónica; Sousa Martín, Carolina; Comino Montilla, Isabel María (Intechopen, 2022)
Celiac disease (CD) is a systemic immune-mediated disorder characterized by a specific serological and histological profile ...
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Consumption of Tritordeum Bread Reduces Immunogenic Gluten Intake without Altering the Gut Microbiota

Haro, Carmen; Guzmán López, M. H.; Marín Sanz, M.; Sánchez León, Susana; Vaquero, Luis; Pastor, Jorge; Comino Montilla, Isabel María; Sousa Martín, Carolina; Vivas, Santiago; Landa, Blanca B.; Barro, Francisco (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Gluten proteins are responsible for the wheat breadmaking quality. However, gluten is also related to human pathologies ...
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Advances in Celiac Disease and Gluten-Free Diet

Comino Montilla, Isabel María; Sousa Martín, Carolina (MDPI, 2022)
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Food Safety and Cross-Contamination of Gluten-Free Products: A Narrative Review

Wieser, Herbert; Segura Montero, Verónica; Ruiz Carnicer, Ángela; Sousa Martín, Carolina; Comino Montilla, Isabel María (MDPI, 2021)
A gluten-free diet (GFD) is currently the only effective treatment for celiac disease (CD); an individual’s daily intake ...
PhD Thesis
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Nuevas estrategias para el control de la enfermedad celíaca: caracterización de los péptidos imunogénicos del gluten y validación clínica de un biomarcador para el seguimiento del paciente celíaco

Ruiz Carnicer, Ángela; Sousa Martín, Carolina; Comino Montilla, Isabel María; Moreno Amador, María de Lourdes (2021)
La enfermedad celiaca (EC) se define como una enteropatía inflamatoria crónica del intestino delgado causada por la ingesta ...
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Rapid, effective, and versatile extraction of gluten in food with application on different immunological methods

Segura Montero, Verónica; Díaz, Jacobo; Ruiz Carnicer, Ángela; Muñoz Suano, Alba; Carrillo Carrión, Carolina; Sousa Martín, Carolina; Cebolla, Ángel; Comino Montilla, Isabel María (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
One of the main concerns in gluten analysis is to achieve efficient extraction of gluten proteins. Conventional ethanol-based ...
Final Degree Project
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Patogenia y epidemiología actualizada del sarampión

Suárez Arrás, Tatiana; Sousa Martín, Carolina; Comino Montilla, Isabel María (2021)
El sarampión es una enfermedad viral grave provocada por el virus del sarampión, que afecta mayoritariamente a los niños. ...
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Oral consumption of bread from an RNAi wheat line with strongly silenced gliadins elicits no immunogenic response in a pilot study with celiac disease patients

Guzmán López, María H.; Sánchez León, Susana; Marín Sanz, Miriam; Comino Montilla, Isabel María; Segura Montero, Verónica; Vaquero, Luis; Rivero Lezcano, Octavio M.; Pastor, Jorge; Sousa Martín, Carolina; Vivas, Santiago; Barro, Francisco (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Celiac disease (CD) is a genetically predisposed, T cell-mediated and autoimmune-like disorder caused by dietary exposure ...
Final Degree Project
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Patologías relacionadas con el consumo de gluten

Torres de la Cruz, María Dolores; Comino Montilla, Isabel María; Sousa Martín, Carolina (2021)
Las reacciones adversas a los alimentos incluyen las intolerancias y alergias alimentarias, que son un problema creciente ...
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Controls and Result Interpretations in Studies of Urine Gluten Peptide Determinations

Sousa Martín, Carolina; Comino Montilla, Isabel María; Cebolla Ramírez, Ángel; Coto, Laura; Segura Montero, Verónica; Ruiz Carnicer, Ángela; Moreno Amador, María de Lourdes (Lippincott, 2021)
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Challenges of monitoring the gluten-free diet adherence in the management and follow-up of patients with celiac disease

Wieser, Herbert; Ruiz Carnicer, Ángela; Segura Montero, Verónica; Comino Montilla, Isabel María; Sousa Martín, Carolina (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Celiac disease (CD) is a chronic gluten-responsive immune mediated enteropathy and is treated with a gluten-free diet ...
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Tritordeum breads are well tolerated with preference over gluten-free breads in non-celiac wheat-sensitive patients and its consumption induce changes in gut bacteria

Sánchez León, Susana; Haro, Carmen; Villatoro, Myriam; Vaquero, Luis; Comino Montilla, Isabel María; González Amigo, Ana B.; Vivas, Santiago; Pastor, Jorge; Sousa Martín, Carolina; Landa, Blanca B.; Barro, Francisco (Wiley-Blackwell, 2021)
BACKGROUND: The ingestion of wheat and other cereals are related to several gut disorders. The specific components responsible ...
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Most Patients With Celiac Disease on Gluten-Free Diets Consume Measurable Amounts of Gluten

Silvester, Jocelyn A.; Comino Montilla, Isabel María; Kelly, Ciarán P.; Sousa Martín, Carolina; Duerksen, Donald R.; Bernstein, Charles N.; Cebolla, Angel; Dominguez, Maria R.; Segura Montero, Verónica; Weiten, Dayna (Elsevier, 2020)
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Exposure Sources, Amounts and Time Course of Gluten Ingestion and Excretion in Patients with Coeliac Disease on a Gluten-free diet

Silvester, Jocelyn A.; Comino Montilla, Isabel María; Rigaux, Lisa N.; Segura Montero, Verónica; Green, Kathy H.; Cebolla, Angel; Weiten, Dayna; Dominguez, Remedios; Leffler, Daniel A.; León, Francisco; Sousa Martín, Carolina; Duerksen, Donald R. (Wiley-Blackwell, 2020)
Background: A major deficit in understanding and improving treatment in coeliac disease (CD) is the lack of empiric data ...
PhD Thesis
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Desarrollo de una metodología de aplicación y lectura de parche cutáneo estandarizado para el diagnóstico y manejo de la alergia a las proteínas de la leche de vaca no IgE mediada

Romero Rueda, María de Gracia; Comino Montilla, Isabel María; Sousa Martín, Carolina (2019)
El presente trabajo de investigación surgió de la necesidad de la creación de un plan de cuidados protocolizado y estandarizado ...
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Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten‐free diet

Comino Montilla, Isabel María; Segura Montero, Verónica; Ortigosa, Luis; Espín Jaime, Beatriz; Castillejo, Gemma; Millán, Antonio; Rodríguez Herrera, Alfonso; Cebolla Ramírez, Ángel; Sousa Martín, Carolina (Wiley, 2019)
Background Treatment for coeliac disease is a lifelong strict gluten‐free diet. Although guidelines recommend regular ...
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Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species

Ruiz Carnicer, Ángela; Comino Montilla, Isabel María; Segura Montero, Verónica; Ozuna Serafini, Carmen Victoria; Moreno Amador, María de Lourdes; López Casado, Miguel Ángel; Torres López, María Isabel; Barro Losada, Francisco; Sousa Martín, Carolina (MDPI, 2019)
The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough ...
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Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition

Sánchez León, Susana; Giménez, María J.; Comino Montilla, Isabel María; Sousa Martín, Carolina; López Casado, Miguel Ángel; Torres, María Isabel; Barro, Francisco (MDPI, 2019)
Wheat gluten proteins are responsible for the bread-making properties of the dough but also for triggering important ...
Final Degree Project
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Papel de la microbiota intestinal en nuestro organismo: una relación de beneficio mutuo

Heredia Barroso, Abel; Sousa Martín, Carolina; Comino Montilla, Isabel María (2018)
L a microbiota intestinal la componen una amplia variedad de especies de bacterias, hongos virus, arqueas y ...
Final Degree Project
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Tratamientoy monitorización de la enfermedad Celiaca

Ciudad Gutiérrez, Pablo; Comino Montilla, Isabel María; Sousa Martín, Carolina (2018)
La enfermedad celíaca (EC) es considerada una patología crónica y sistémica desencadenada por ...
Final Degree Project
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Prevalencia mundial de la enfermedad celíaca

Muñoz Tello, Paola; Comino Montilla, Isabel María; Sousa Martín, Carolina (2018)
La enfermedad celíaca (EC) se define como una enteropatía inflamatoria crónica del intestino delgado mediada inmunológicamente ...
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The Dietary Intervention of Transgenic Low-Gliadin Wheat Bread in Patients with Non-Celiac Gluten Sensitivity (NCGS) Showed No Differences with Gluten Free Diet (GFD) but Provides Better Gut Microbiota Profile

Haro, Carmen; Villatoro, Myriam; Vaquero, Luis; Pastor, Jorge; Giménez, María J.; Ozuna Serafini, Carmen Victoria; Sánchez León, Susana; García Molina, María Dolores; Segura Montero, Verónica; Comino Montilla, Isabel María; Sousa Martín, Carolina (MDPI, 2018)
The study evaluated the symptoms, acceptance, and digestibility of bread made from transgenic low-gliadin wheat, in ...
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Biomarkers to monitor gluten-free diet compliance in celiac patients

Moreno Amador, María de Lourdes; Rodríguez Herrera, Alfonso; Sousa Martín, Carolina; Comino Montilla, Isabel María (MDPI, 2017)
Gluten-free diet (GFD) is the only treatment for celiac disease (CD). There is a general consensus that strict GFD adherence ...
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Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing

Moreno Amador, María de Lourdes; Cebolla, Ángel; Muñoz Suano, Alba; Carrillo Carrión, Carolina; Comino Montilla, Isabel María; Pizarro, Ángeles; Sousa Martín, Carolina (BMJ Publishing Group, 2017)
Objective Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance ...
Final Degree Project
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Uso de marcadores no invasivos para el seguimiento de la dieta sin gluten en pacientes celíacos pediátricos

Segura Montero, Verónica; Comino Montilla, Isabel María (2017)
El tratamiento actual de la enfermedad celíaca (EC) es una estricta dieta sin gluten (DSG) durante toda la vida. Es una ...
Final Degree Project
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Estudio de la adherencia a la dieta sin gluten en pacientes celíacos pediátricos mediante la cuantificación de péptidos inmunogénicos del gluten en heces

Lao Domínguez, Francisco Ángel; Comino Montilla, Isabel María; Sousa Martín, Carolina (2016)
La enfermedad celíaca (EC) es un desorden clínico basado en una intolerancia al gluten presente en ciertos cereales como ...
Final Degree Project
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Detección de la fracción inmunotóxica del gluten en diferentes especies de cereales y su implicación en la enfermedad celíaca

García Lloret, Patricia; Sousa Martín, Carolina; Comino Montilla, Isabel María (2016)
La enfermedad celíaca (EC) es una patología que afecta al intestino delgado proximal y está asociada a una intolerancia ...
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Targeting of prolamins by RNAi in bread wheat: Effectiveness of seven silencing-fragment combinations for obtaining lines devoid of coeliac disease epitopes from highly immunogenic gliadins

Barro, Francisco; Iehisa, Julio C. M.; Giménez, María J.; García Molina, María D.; Ozuna Serafini, Carmen Victoria; Comino Montilla, Isabel María; Sousa Martín, Carolina; Gil Humanes, Javier (Wiley-Blackwell, 2016)
Gluten proteins are responsible for the viscoelastic properties of wheat flour but also for triggering pathologies in ...
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Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients

Comino Montilla, Isabel María; Fernández Bañares, Fernando; Segura Montero, Verónica; Sousa Martín, Carolina; Esteve, María; Ortigosa, Luis (Nature Publishing Group, 2016)
Objectives: Treatment for celiac disease (CD) is a lifelong strict gluten-free diet (GFD). Patients should be followed-up ...
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Identification and molecular characterization of oat peptides implicated on coeliac immune response

Comino Montilla, Isabel María; Bernardo, David; Bancel, Emmanuelle; Moreno Amador, María de Lourdes; Sánchez, Borja; Barro, Francisco; Šuligoj, Tanja; Ciclitira, Paul Jonathan; Cebolla, Ángel; Knight, Stella Catherine; Branlard, Gérard; Sousa Martín, Carolina (Co-Action Publishing, 2016)
Background : Oats provide important nutritional and pharmacological properties, although their safety in coeliac ...
Final Degree Project
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Implicaciones clínicas asociadas a las infecciones provocadas por helicobacter pylori

Ballesta López, María de los Ángeles; Comino Montilla, Isabel María (2016)
Helicobacter pylori fue redescubierta en 1983 por los patólogos Warren y Marshall, tras demostrar su presencia en la mucosa ...
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Role of oats in celiac disease

Comino Montilla, Isabel María; Moreno Amador, María de Lourdes; Sousa Martín, Carolina (Baishideng Publishing Group, 2015)
A gluten-free diet is currently the only effective means of treating individuals with celiac disease. Such a diet enables ...
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Alternative grains as potential raw material for gluten– free food development in the diet of celiac and gluten– sensitive patients

Moreno Amador, María de Lourdes; Comino Montilla, Isabel María; Sousa Martín, Carolina (Austin Publishing Group, 2014)
Celiac disease is an autoimmune disorder resulting from gluten intolerance and is based on a genetic predisposition. Gluten ...
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Reduced-gliadin wheat bread: An alternative to the gluten-free diet for consumers suffering gluten-related pathologies

Gil Humanes, Javier; Pistón, Fernando; Altamirano Fortoul, Rossana; Real, Ana; Comino Montilla, Isabel María; Sousa Martín, Carolina; Rossell, Cristina M.; Barro, Francisco (Public Library of Science, 2014)
Wheat flour cannot be tolerated by those who suffer allergies to gluten. Human pathologies associated with grain proteins ...
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Constitutive gut-homing capacity on circulating myeloid dendritic cells in coeliac disease

Comino Montilla, Isabel María; Šuligoj, Tanja; Al-Hassi, Hafid Omar; Lee, Gui Han; Sousa Martín, Carolina; Landy, Jonathan; Ciclitira, Paul Jonathan; Knight, Stella Catherine; Bernardo, David (Arán Ediciones, S.L., 2014)
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Update on nutritional aspects of gluten-free diet in celiac patients

Moreno Amador, María de Lourdes; Comino Montilla, Isabel María; Sousa Martín, Carolina (Asian Medical Journals, 2014)
A strict gluten - free diet is the only currently available therapeutic treatment for patients with celiac disease, an ...
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Identification and in Vitro reactivity of celiac immunoactive peptides in an apparent gluten-free beer

Real, Ana; Comino Montilla, Isabel María; Moreno Amador, María de Lourdes; López Casado, Miguel Ángel; Lorite, Pedro; Cebolla, Ángel; Sousa Martín, Carolina (Public Library of Science, 2014)
Gluten content from barley, rye, wheat and in certain oat varieties, must be avoid in individuals with celiac disease. In ...
Patent. Invention
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Determinación de niveles de péptidos inmunogénicos del gluten en muestras humanas

Sousa Martín, Carolina; Comino Montilla, Isabel María; Real calderón, Ana; Vivas Alegre, Santiago; Cebolla Ramírez, Ángel (Oficina Española de Patentes y Marcas (OEPM), 2013)
La presente invención, encuadrada en el sector médico-clínico, muestra un procedimiento para la monitorización de la ...
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The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients

Comino Montilla, Isabel María; Moreno Amador, María de Lourdes; Real, Ana; Rodríguez Herrera, Alfonso; Barro, Francisco; Sousa Martín, Carolina (Multidisciplinary Digital Publishing Institute (MDPI), 2013)
A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, ...
Patent. Invention
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Procedimiento para la selección de semillas de cereales aptas para ser consumidas por los enfermos celíacos.

Comino Montilla, Isabel María; Real calderón, Ana; Sousa Martín, Carolina (Oficina Española de Patentes y Marcas , 2012)
La presente invención se refiere a un procedimiento sencillo para la selección de variedades de semillas de trigo, cebada, ...
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Molecular and Immunological Characterization of Gluten Proteins Isolated from Oat Cultivars That Differ in Toxicity for Celiac Disease

Real, Ana; Comino Montilla, Isabel María; Lorenzo, Laura de; Merchán Ignacio, Francisco; Gil Humanes, Javier; Giménez, María J.; López Casado, Miguel Ángel; Torres, Mª Isabel; Cebolla, Ángel; Sousa Martín, Carolina; Barro, Francisco; Pistón, Fernando (Public Library of Science, 2012)
A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease ...
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Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces

Comino Montilla, Isabel María; Real calderón, Ana; Vivas, Santiago; Síglez, Miguel Ángel; Caminero, Alberto; Nistal, Esther; Casqueiro, Javier; Rodríguez Herrera, Alfonso; Cebolla, Ángel; Sousa Martín, Carolina (Oxford University Press, 2012)
Background: Certain immunotoxic peptides from gluten are resistant to gastrointestinal digestion and can interact with ...
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Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease

Comino Montilla, Isabel María; Lorenzo Barrios, Laura de; Cornell, Hugh; López Casado, Miguel Ángel; Barro, Francisco; Sousa Martín, Carolina (BMJ Publishing Group, 2011)
Background and aims Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially ...
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Toward the Assessment of Food Toxicity for Celiac Patients: Characterization of Monoclonal Antibodies to a Main Immunogenic Gluten Peptide

Morón Flores, Belén; Bethune, Michael T.; Comino Montilla, Isabel María; Manyani, Hamid; Ferragud, Marina; López, Manuel Carlos; Cebolla, Ángel; Khosla, Chaitan; Sousa Martín, Carolina (Public Library of Science, 2008)
Background and Aims: Celiac disease is a permanent intolerance to gluten prolamins from wheat, barley, rye and, in some ...