dc.creator | Alba Jiménez, Gonzalo | es |
dc.creator | Reyes Quiroz, María Edith | es |
dc.creator | Santa-María Pérez, Consuelo | es |
dc.creator | Ramírez, Remedios | es |
dc.creator | Geniz, Isabel | es |
dc.creator | Jiménez Carrasco, Juan | es |
dc.creator | Martín Nieto, José | es |
dc.creator | Pintado Sanjuán, Elizabeth | es |
dc.creator | Sobrino Beneyto, Francisco | es |
dc.date.accessioned | 2016-05-31T10:01:29Z | |
dc.date.available | 2016-05-31T10:01:29Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Alba Jiménez, G., Reyes Quiroz, M.E., Santa-María Pérez, C., Ramírez, R., Geniz, I., Jiménez Carrasco, J.,...,Sobrino Beneyto, F. (2012). Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils. PLoS ONE, 7 (10), 1-13. | |
dc.identifier.issn | 1932-6203 | es |
dc.identifier.uri | http://hdl.handle.net/11441/41714 | |
dc.description.abstract | Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. They play important
roles in controlling cholesterol homeostasis and as regulators of inflammatory gene expression and innate immunity, by
blunting the induction of classical pro-inflammatory genes. However, opposite data have also been reported on the
consequences of LXR activation by oxysterols, resulting in the specific production of potent pro-inflammatory cytokines and
reactive oxygen species (ROS). The effect of the inflammatory state on the expression of LXRs has not been studied in
human cells, and constitutes the main aim of the present work. Our data show that when human neutrophils are triggered
with synthetic ligands, the synthesis of LXRa mRNA became activated together with transcription of the LXR target genes
ABCA1, ABCG1 and SREBP1c. An inflammatory mediator, 15-deoxy-D12,14-prostaglandin J2 (15dPGJ2), hindered T0901317-
promoted induction of LXRa mRNA expression together with transcription of its target genes in both neutrophils and
human macrophages. This down-regulatory effect was dependent on the release of reactive oxygen species elicited by
15dPGJ2, since it was enhanced by pro-oxidant treatment and reversed by antioxidants, and was also mediated by ERK1/2
activation. Present data also support that the 15dPGJ2-induced serine phosphorylation of the LXRa molecule is mediated by
ERK1/2. These results allow to postulate that down-regulation of LXR cellular levels by pro-inflammatory stimuli might be
involved in the development of different vascular diseases, such as atherosclerosis | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Public Library of Science | es |
dc.relation.ispartof | PLoS ONE, 7 (10), 1-13. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.publisherversion | 10.1371/journal.pone.0042195 | es |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0042195 | es |
idus.format.extent | 13 p. | es |
dc.journaltitle | PLoS ONE | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 13 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/41714 | |