dc.creator | Abilés, Jimena | es |
dc.creator | Pérez de la Cruz, Antonio Jesús | es |
dc.creator | Castaño, José García | es |
dc.creator | Rodríguez Elvira, Manuel | es |
dc.creator | Aguayo, Eduardo | es |
dc.creator | Moreno Torres, Rosario | es |
dc.creator | Llopis, Juan Emilio | es |
dc.creator | Aranda, Pilar | es |
dc.creator | Argüelles Castilla, Sandro | es |
dc.creator | Ayala Gómez, Antonio | es |
dc.creator | Machado Quintana, Alberto | es |
dc.creator | Planells, Elena María | es |
dc.date.accessioned | 2016-05-24T12:36:43Z | |
dc.date.available | 2016-05-24T12:36:43Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Abilés, J., Pérez de la Cruz, A.J., Castaño, J.G., Rodríguez Elvira, M., Aguayo, E., Moreno Torres, R.,...,Planells, E.M. (2006). Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study. Critical Care, 10 (5), 1-9. | |
dc.identifier.issn | 1466-609X | es |
dc.identifier.uri | http://hdl.handle.net/11441/41541 | |
dc.description.abstract | Critically ill patients suffer from oxidative stress
caused by reactive oxygen species (ROS) and reactive nitrogen
species (RNS). Although ROS/RNS are constantly produced
under normal circumstances, critical illness can drastically
increase their production. These patients have reduced plasma
and intracellular levels of antioxidants and free electron
scavengers or cofactors, and decreased activity of the
enzymatic system involved in ROS detoxification. The prooxidant/
antioxidant balance is of functional relevance during
critical illness because it is involved in the pathogenesis of
multiple organ failure. In this study the objective was to evaluate
the relation between oxidative stress in critically ill patients and
antioxidant vitamin intake and severity of illness.
Methods Spectrophotometry was used to measure in plasma
the total antioxidant capacity and levels of lipid peroxide,
carbonyl group, total protein, bilirubin and uric acid at two time
points: at intensive care unit (ICU) admission and on day seven.
Daily diet records were kept and compliance with
recommended dietary allowance (RDA) of antioxidant vitamins
(A, C and E) was assessed.
Results Between admission and day seven in the ICU,
significant increases in lipid peroxide and carbonyl group were
associated with decreased antioxidant capacity and greater
deterioration in Sequential Organ Failure Assessment score.
There was significantly greater worsening in oxidative stress
parameters in patients who received antioxidant vitamins at
below 66% of RDA than in those who received antioxidant
vitamins at above 66% of RDA. An antioxidant vitamin intake
from 66% to 100% of RDA reduced the risk for worsening
oxidative stress by 94% (ods ratio 0.06, 95% confidence
interval 0.010 to 0.39), regardless of change in severity of illness
(Sequential Organ Failure Assessment score).
Conclusion The critical condition of patients admitted to the
ICU is associated with worsening oxidative stress. Intake of
antioxidant vitamins below 66% of RDA and alteration in
endogenous levels of substances with antioxidant capacity are
related to redox imbalance in critical ill patients. Therefore, intake
of antioxidant vitamins should be carefully monitored so that it is
as close as possible to RDA | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer Science + Business Media | es |
dc.relation.ispartof | Critical Care, 10 (5), 1-9. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: A cohort study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | 10.1186/cc5068 | es |
dc.identifier.doi | http://dx.doi.org/10.1186/cc5068 | es |
idus.format.extent | 9 p. | es |
dc.journaltitle | Critical Care | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 9 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/41541 | |