Repositorio de producción científica de la Universidad de Sevilla

Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii

Opened Access Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii

Citas

buscar en

Estadísticas
Icon
Exportar a
Autor: López Lázaro, Miguel
Palma de la Peña, Nieves
Pastor Carrillo, Nuria María
Martín Cordero, Carmen
Navarro, Eduardo
Cortés, Felipe
Ayuso, María Jesús
Toro, María Victoria
Departamento: Universidad de Sevilla. Departamento de Biología Celular
Fecha: 2003
Publicado en: Planta Medica, 69, 701-704
Tipo de documento: Artículo
Resumen: Recent research has shown the anticancer effects of digitalis compounds suggesting their possible use in medical oncology. Four extracts obtained from the leaves of Digitalis purpurea subsp. heywoodii have been assessed for cytotoxic activity against three human cancer cell lines,using the SRB assay. All of them showed high cytotoxicity,producing IC50 values in the 0.78 - 15 1gfmL range with the methanolic extract being the most active,in non toxic concentrations. Steroid glycosides (gi- toxigenin derivatives) were detected in this methanolic extract. Gitoxigenin and gitoxin were evaluated in the SRB assay using the three human cancer cell lines,showing IC50 values in the 0.13 - 2.8 1M range,with the renal adenocarcinoma cancer cell line (TK-10) being the most sensitive one. Morphological apopto- sis evaluation of the methanolic extract and both compounds on the TK-10 cell line showed that their cytotoxicity was mediated by an apoptotic effect. Finally,possible mechanisms involved ...
[Ver más]
Tamaño: 69.07Kb
Formato: PDF

URI: http://hdl.handle.net/11441/41108

DOI: http://dx.doi.org/10.1055/s-2003-42789

Mostrar el registro completo del ítem


Esta obra está bajo una Licencia Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internacional

Este registro aparece en las siguientes colecciones