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Regulation of Gephyrin Cluster Size and Inhibitory Synaptic Currents on Renshaw Cells by Motor Axon Excitatory Inputs

Opened Access Regulation of Gephyrin Cluster Size and Inhibitory Synaptic Currents on Renshaw Cells by Motor Axon Excitatory Inputs

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Autor: González Forero, David
Pastor Loro, Ángel Manuel
Geiman, Eric J.
Benítez Temiño, Beatriz
Alvarez, Francisco J.
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2005
Publicado en: Journal of Neuroscience, 25(2), 417-429
Tipo de documento: Artículo
Resumen: Renshaw cells receive a high density of inhibitory synapses characterized by large postsynaptic gephyrin clusters and mixed glycinergic/ GABAergic inhibitory currents with large peak amplitudes and long decays. These properties appear adapted to increase inhibitory efficacy over Renshaw cells and mature postnatally by mechanisms that are unknown. We tested the hypothesis that heterosynaptic influences from excitatory motor axon inputs modulate the development of inhibitory synapses on Renshaw cells. Thus, tetanus (TeNT) and botulinum neurotoxin A (BoNT-A) were injected intramuscularly at postnatal day 5 (P5) to, respectively, elevate or reduce motor axon firing activity for 2 weeks. After TeNT injections, the average gephyrin cluster areas on Renshaw cells increased by 18.4% at P15 and 28.4% at P20 and decreased after BoNT-A injections by 17.7% at P15 and 19.9% at P20. The average size differences resulted from changes in the proportions of small and large gephyrin clusters. W...
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Tamaño: 681.9Kb
Formato: PDF

URI: http://hdl.handle.net/11441/40719

DOI: http://dx.doi.org/10.1523/JNEUROSCI.3725-04.2005

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