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Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells

Opened Access Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells

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Autor: Talaverón Aguilocho, Rocío
Fernández, Paola
Escamilla, Rosalba
Pastor Loro, Ángel Manuel
Rodríguez Matarredona, Esperanza
Sáez, Juan Carlos
Departamento: Universidad de Sevilla. Departamento de Fisiología
Fecha: 2015
Publicado en: Frontiers in Cellular Neuroscience, 9 (411)
Tipo de documento: Artículo
Resumen: The postnatal subventricular zone (SVZ) lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) that generate new olfactory bulb interneurons. Communication via gap junctions between cells in the SVZ is involved in NPC proliferation and in neuroblast migration towards the olfactory bulb. SVZ NPCs can be expanded in vitro in the form of neurospheres that can be used for transplantation purposes after brain injury. We have previously reported that neurosphere-derived NPCs form heterocellular gap junctions with host glial cells when they are implanted after mechanical injury. To analyze functionality of NPC-glial cell gap junctions we performed dye coupling experiments in co-cultures of SVZ NPCs with astrocytes or microglia. Neurosphere-derived cells expressed mRNA for at least the hemichannel/gap junction channel proteins connexin 26 (Cx26), Cx43, Cx45 and pannexin 1 (Panx1). Dye coupling experiments revealed that gap junctional communication occurred among ne...
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Tamaño: 1.030Mb
Formato: PDF

URI: http://hdl.handle.net/11441/39993

DOI: http://dx.doi.org/10.3389/fncel.2015.00411

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