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Administration of L-arginine reduces the delay of the healing process caused by Ibuprofen. Implication of COX and growth factors expression

Opened Access Administration of L-arginine reduces the delay of the healing process caused by Ibuprofen. Implication of COX and growth factors expression
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Autor: Sánchez Fidalgo, Susana
Martín Lacave, Inés María
Illanes, Matilde
Bruseghini, Leo
Esteras, Antonio
Motilva Sánchez, Virginia
Departamento: Universidad de Sevilla. Departamento de Farmacología
Fecha: 2005
Publicado en: Histology and Histopathology, 20 (2), 437-447
Tipo de documento: Artículo
Resumen: The objective of the present study has been to advance knowledge of the gastric role played by the amino acid L-Arginine (L-Arg) in the evolution of a chronic gastric ulcer. In order to clarify it, L-Arg alone or together with Ibuprofen have been administrated in an experimental acetic acid chronic ulcer, analysing characteristic parameters of an active curative process, such as PGE2 production, COX expression, and also angiogenesis, proliferation/apoptosis and growth factors expression. Our results reveal that L-Arg is favourable in the healing process improving the curative course. Ibuprofen caused a delay in ulcer healing, more evident 14 days after ulcer induction; COX-2 expression was increased at the 7th day although no signal of protein could be detected after 14 days; PGE2 production was inhibited in intact and ulcerated areas at both times assayed. In contrast, treatment with L-Arg reduced the delay of the lesion, the increment in COX-2 expression induced by Ibuprofen, and wa...
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URI: http://hdl.handle.net/11441/38873

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