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Anti-inflammatory effects of adrenomedullin on acute lung injury induced by Carrageenan in mice

Opened Access Anti-inflammatory effects of adrenomedullin on acute lung injury induced by Carrageenan in mice

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Autor: Talero Barrientos, Elena Mª
Di Paola, Rosanna
Mazzon, Emanuela
Esposito, Emanuela
Motilva Sánchez, Virginia
Cuzzocrea, Salvatore
Departamento: Universidad de Sevilla. Departamento de Farmacología
Fecha: 2012
Publicado en: Mediators of inflammation, 2012 (2012), 717851
Tipo de documento: Artículo
Resumen: Adrenomedullin (AM) is a 52 amino acid peptide that has shown predominant anti-inflammatory activities. In the present study, we evaluated the possible therapeutic effect of this peptide in an experimental model of acute inflammation, the carrageenan-(CAR-) induced pleurisy. Pleurisy was induced by injection of CAR into the pleural cavity of mice. AM (200 ng/kg) was administered by intraperitoneal route 1 h after CAR, and the animals were sacrificed 4 h after that. AM treatment attenuated the recruitment of leucocytes in the lung tissue and the generation and/or the expression of the proinflammatory cytokines as well as the expression of the intercellular cell adhesion molecules. Moreover, AM inhibited the induction of inducible nitric oxide synthase (iNOS), thereby abating the generation of nitric oxide (NO) and prevented the oxidative and nitroxidative lung tissue injury, as shown by the reduction of nitrotyrosine, malondialdehyde (MDA), and poly (ADP-ribose) polymerase (PARP) levels. Fi...
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Tamaño: 4.366Mb
Formato: PDF

URI: http://hdl.handle.net/11441/38809

DOI: http://dx.doi.org/10.1155/2012/717851

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