dc.creator | Talero Barrientos, Elena Mª | |
dc.creator | García-Mauriño Ruiz-Berdejo, Sofía | |
dc.creator | Ávila Román, Francisco Javier | |
dc.creator | Rodríguez Luna, Azahara María | |
dc.creator | Alcaide Molina, Antonio Javier | |
dc.creator | Motilva Sánchez, Virginia | |
dc.date.accessioned | 2016-03-18T10:33:49Z | |
dc.date.available | 2016-03-18T10:33:49Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1660-3397 | es |
dc.identifier.uri | http://hdl.handle.net/11441/38805 | |
dc.description.abstract | The risk of onset of cancer is influenced by poorly controlled chronic
inflammatory processes. Inflammatory diseases related to cancer development include
inflammatory bowel disease, which can lead to colon cancer, or actinic keratosis,
associated with chronic exposure to ultraviolet light, which can progress to squamous cell
carcinoma. Chronic inflammatory states expose these patients to a number of signals with
tumorigenic effects, including nuclear factor kappa B (NF-κB) and mitogen-activated
protein kinases (MAPK) activation, pro-inflammatory cytokines and prostaglandins release
and ROS production. In addition, the participation of inflammasomes, autophagy and
sirtuins has been demonstrated in pathological processes such as inflammation and cancer.
Chemoprevention consists in the use of drugs, vitamins, or nutritional supplements to
reduce the risk of developing or having a recurrence of cancer. Numerous in vitro and
animal studies have established the potential colon and skin cáncer. Numerous in vitro and
animal studies have established the potential colon and skin cancer chemopreventive
properties of substances from marine environment, including microalgae species and their
products (carotenoids, fatty acids, glycolipids, polysaccharides and proteins). This review
summarizes the main mechanisms of actions of these compounds in the chemoprevention
of these cancers. These actions include suppression of cell proliferation, induction of
apoptosis, stimulation of antimetastatic and antiangiogenic responses and increased
antioxidant and anti-inflammatory activity. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | Marine Drugs, 13 (10), 6152-6209 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Chronic inflammation | es |
dc.subject | Colon cancer | es |
dc.subject | Skin cancer | es |
dc.subject | Chemoprevention | es |
dc.subject | Microalgae | es |
dc.title | Bioactive compounds isolated from microalgae in chronic inflammation and cancer | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Vegetal y Ecología | es |
dc.relation.publisherversion | 10.3390/md13106152 | es |
dc.identifier.doi | http://dx.doi.org/10.3390/md13106152 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/38805 | |