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Bioactive compounds isolated from microalgae in chronic inflammation and cancer

Opened Access Bioactive compounds isolated from microalgae in chronic inflammation and cancer


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Autor: Talero Barrientos, Elena Mª
García-Mauriño, Sofía
Ávila Román, Francisco Javier
Rodríguez Luna, Azahara María
Alcaide Molina, Antonio Javier
Motilva Sánchez, Virginia
Departamento: Universidad de Sevilla. Departamento de Farmacología
Universidad de Sevilla. Departamento de Biología Vegetal y Ecología
Fecha: 2015
Publicado en: Marine Drugs, 13 (10), 6152-6209
Tipo de documento: Artículo
Resumen: The risk of onset of cancer is influenced by poorly controlled chronic inflammatory processes. Inflammatory diseases related to cancer development include inflammatory bowel disease, which can lead to colon cancer, or actinic keratosis, associated with chronic exposure to ultraviolet light, which can progress to squamous cell carcinoma. Chronic inflammatory states expose these patients to a number of signals with tumorigenic effects, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) activation, pro-inflammatory cytokines and prostaglandins release and ROS production. In addition, the participation of inflammasomes, autophagy and sirtuins has been demonstrated in pathological processes such as inflammation and cancer. Chemoprevention consists in the use of drugs, vitamins, or nutritional supplements to reduce the risk of developing or having a recurrence of cancer. Numerous in vitro and animal studies have established the potential colon a...
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