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Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats


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dc.creator Vázquez Castilla, Sara
dc.creator Puerta Vázquez, Rocío de la
dc.creator García Giménez, María Dolores
dc.creator Guillén Bejarano, Rafael
dc.creator Fernández Arche, María de los Ángeles 2016-03-18T10:32:03Z 2016-03-18T10:32:03Z 2013
dc.identifier.issn 1661-6596 es
dc.description.abstract We have previously shown that the Andalusian-cultivated Asparagus officinalis L. “triguero” variety produces hypocholesterolemic and hepatoprotective effects on rats. This asparagus is a rich source of phytochemicals although we hypothesized there would be some of them more involved in these functional properties. Thus, we aimed to study the effects of asparagus (500 mg/kg body weight (bw)/day) and their partially purified fractions in flavonoids (50 mg/kg bw/day), saponins (5 mg/kg bw/day) and dietary fiber (500 mg/kg bw/day) on oxidative status and on lipid profile in rats fed a cholesterol-rich diet. After 5 weeks treatment, plasma lipid values, hepatic enzyme activities and liver malondialdehyde (MDA) concentrations were measured. With the exception of the saponin fraction (SF), the administration of lyophilized asparagus (LA), fiber fraction (FF), and flavonoid fraction (FVF) to hypercholesterolemic rats produced a significant hypolipidemic effect compare to a high-cholesterol diet (HCD). In addition, the LA and FVF groups exhibited a significant increase in enzyme activity from multiple hepatic antioxidant systems including: superoxide dismutase, catalase, and gluthatione reductase/peroxidase as well as a decrease in MDA concentrations compared to HCD group. These results demonstrate that “triguero” asparagus possesses bioactive constituents, especially dietary fiber and flavonoids, that improve the plasma lipid profile and prevent hepatic oxidative damage under conditions of hypercholesterolemia. es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Multidisciplinary Digital Publishing Institute (MDPI) es
dc.relation.ispartof International Journal of Molecular Sciences, 14, 21227-21239 es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri *
dc.subject Flavonoids es
dc.subject Fibers es
dc.subject Saponins es
dc.subject Rats es
dc.subject “Triguero” asparagus es
dc.subject Diet-induced hypercholesterolemia es
dc.subject Plasma lipids es
dc.subject Hepatic antioxidant enzymes es
dc.title Bioactive constituents from "triguero" asparagus improve the plasma lipid profile and liver antioxidant status in hypercholesterolemic rats es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Farmacología es
dc.relation.publisherversion 10.3390/ijms141121227 es
dc.identifier.doi es
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