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Preference for guanosine at first codon position in highly expressed Escherichia coli genes. A relationship with translational efficiency

 

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dc.creator Gutiérrez Pozo, Gabriel
dc.creator Márquez, Lorenzo
dc.creator Marín, Antonio
dc.date.accessioned 2016-03-03T08:32:47Z
dc.date.available 2016-03-03T08:32:47Z
dc.date.issued 1996
dc.identifier.issn 0305-1048 es
dc.identifier.uri http://hdl.handle.net/11441/36772
dc.description.abstract The variation in base composition at the three codon sites in relation to gene expressivity, the latter esti- mated by the Codon Adaptation Index, has been studied in a sample of 1371 Escherichia coli genes. Correlation and regression analyses show that in- creasing expression levels are accompanied by higher frequencies of base G at first, of base A at second and of base C at third codon positions. However, correla- tion between expressivity and base compositional biases at each codon site was only significant and positive at first codon position. The preference for G-starting codons as gene expression level increases is discussed in terms of translational optimization es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Oxford University Press es
dc.relation.ispartof Nucleic Acids Research, 24, 2525-2527 es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Guanosine es
dc.subject Bacterial gene es
dc.subject Codon usage es
dc.subject Dna base composition es
dc.subject Escherichia coli es
dc.subject Gene expression es
dc.subject Nonhuman es
dc.subject Priority journal es
dc.subject Regression analysis es
dc.subject Rna translation es
dc.title Preference for guanosine at first codon position in highly expressed Escherichia coli genes. A relationship with translational efficiency es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Genética es
dc.relation.publisherversion 10.1093/nar/24.13.2525 es
dc.identifier.doi http://dx.doi.org/10.1093/nar/24.13.2525 es
dc.identifier.idus https://idus.us.es/xmlui/handle/11441/36772
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