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Terminal osteoblast differentiation, mediated by runx2 and p27 KIP1, is disrupted in osteosarcoma

 

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Opened Access Terminal osteoblast differentiation, mediated by runx2 and p27 KIP1, is disrupted in osteosarcoma
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Author: Gutiérrez Pozo, Gabriel
Thomas, David M.
Johnson, Sandra A.
Sims, Natalie A.
Trivett, Melanie K.
Slavin, John L.
Rubin, Brian P.
Waring, Paul
McArthur, Grant A.
Walkley, Carl R.
Holloway, Andrew J.
Diyagama, Dileepa
Grim, Jonathon E.
Clurman, Bruce E.
Bowtell, David D. L.
Lee, Jong-Seo
Piscopo, Denise M.
Carty, Shannon A.
Hinds, Philip W.
Department: Universidad de Sevilla. Departamento de Genética
Date: 2004
Published in: Journal of Cell Biology, 167, 925-934
Document type: Article
Abstract: The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteo-blast differentiation belonging to the runt family of tumor suppressor genes, is consistently d...
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URI: http://hdl.handle.net/11441/36714

DOI: http://dx.doi.org/10.1083/jcb.200409187

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