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Bile-induced curing of the virulence plasmid in Salmonella enterica serovar typhimurium

 

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Opened Access Bile-induced curing of the virulence plasmid in Salmonella enterica serovar typhimurium
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Author: Ramos Morales, Francisco
García Quintanilla, Meritxell de Jesús
Prieto Ortega, Ana Isabel
Barnes, Laurent
Casadesús Pursals, Josep
Department: Universidad de Sevilla. Departamento de Genética
Date: 2006
Published in: Journal of Bacteriology, 88 (22), 7963-7965
Document type: Article
Abstract: Exposure to bile induces curing of the virulence plasmid in Salmonella enterica serovar Typhimurium (pSLT). Disruption of the ccdB gene increases pSLT curing, both spontaneous and induced by bile, suggesting that the pSLT ccdAB genes may encode a homolog of the CcdAB addiction module previously described in the F sex factor. Unlike the F sex factor, synthesis of pSLT-encoded pili does not confer bile sensitivity. These observations may provide insights into the evolution of virulence plasmids in Salmonella subspecies I, as well as the causes of virulence plasmid loss in other Salmonella subspecies
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URI: http://hdl.handle.net/11441/36681

DOI: 10.1128/JB.00995-06

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