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The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes

 

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Opened Access The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne Syndrome-like phenotypes
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Author: Herrera Moyano, Emilia
Moriel Carretero, María
Montelone, Beth A.
Aguilera López, Andrés
Department: Universidad de Sevilla. Departamento de Genética
Date: 2014
Published in: PLoS Genetics, 10(12), 1-14
Document type: Article
Abstract: The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three yeast mutations of the Rad3/XPD helicase of TFIIH known as rem (recombination and mutation phenotypes). We found that, in these mu...
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URI: http://hdl.handle.net/11441/29113

DOI: http://dx.doi.org/10.1371/journal.pgen.1004859

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